105d
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(New page: 200px<br /> <applet load="105d" size="450" color="white" frame="true" align="right" spinBox="true" caption="105d" /> '''SOLUTION STRUCTURES OF THE I-MOTIF TETRAMER...)
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SOLUTION STRUCTURES OF THE I-MOTIF TETRAMERS OF D(TCC), D(5MCCT) AND D(T5MCC). NOVEL NOE CONNECTIONS BETWEEN AMINO PROTONS AND SUGAR PROTONS
Overview
BACKGROUND: At slightly acid or even neutral pH, oligodeoxynucleotides, that include a stretch of cytidines form a tetramer structure in which two, parallel-stranded duplexes have their hemi-protonated C.C+ base pairs, face-to-face and fully intercalated, in a so-called i-motif, first, observed serendipitously in [d(TC5)]4. RESULTS: A high-definition, structure of [d(TCC)]4 was computed on the basis of inter-residue, distances corresponding to 21 NOESY cross-peaks measured at short mixing, times. A similarly defined structure of [d(5mCCT)]4 was also obtained. A, small number of very characteristic (amino proton)-(sugar proton), cross-peaks entails the intercalation topology. The structure is generally, similar to that of [d(TC5)]4. The sequence d(T5mCC) forms two tetramers in, comparable ... [(full description)]
About this Structure
105D is a [Protein complex] structure of sequences from [[1]]. Full crystallographic information is available from [OCA].
Reference
Solution structures of the i-motif tetramers of d(TCC), d(5methylCCT) and d(T5methylCC): novel NOE connections between amino protons and sugar protons., Leroy JL, Gueron M, Structure. 1995 Jan 15;3(1):101-20. PMID:7743125
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