1w51
From Proteopedia
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| - | [[Image:1w51.gif|left|200px]]<br /> | + | [[Image:1w51.gif|left|200px]]<br /><applet load="1w51" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1w51" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1w51, resolution 2.55Å" /> | caption="1w51, resolution 2.55Å" /> | ||
'''BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON-PEPTIDIC INHIBITOR'''<br /> | '''BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON-PEPTIDIC INHIBITOR'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1W51 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with IOD and L01 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] | + | 1W51 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with IOD and L01 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Known structural/functional Site: <scene name='pdbsite=AC1:L01 Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W51 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:30:40 2007'' |
Revision as of 16:20, 18 December 2007
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BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON-PEPTIDIC INHIBITOR
Overview
Human BACE, also known as beta-secretase, shows promise as a potential, therapeutic target for Alzheimer's disease. We determined the apo, structure of BACE to 1.75 A, and a structure of a hydroxyethylamine, inhibitor complex derived by soaking. These show significant active-site, movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by, structure-based drug design.
About this Structure
1W51 is a Single protein structure of sequence from Homo sapiens with IOD and L01 as ligands. Active as Memapsin 2, with EC number 3.4.23.46 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Apo and inhibitor complex structures of BACE (beta-secretase)., Patel S, Vuillard L, Cleasby A, Murray CW, Yon J, J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669
Page seeded by OCA on Tue Dec 18 18:30:40 2007
Categories: Homo sapiens | Memapsin 2 | Single protein | Cleasby, A. | Murray, C.W. | Patel, S. | Vuillard, L. | Yon, J. | IOD | L01 | Alternative splicing | Alzheimer's disease | Aspartic protease | Aspartyl protease | Base | Beta-secretase | Glycoprotein | Hydrolase | Signal | Transmembrane | Zymogen
