3lu9

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===Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1===
===Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1===
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{{ABSTRACT_PUBMED_20236938}}
==Disease==
==Disease==
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==Reference==
==Reference==
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thrombin]]
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Revision as of 04:36, 26 May 2010

Image:3lu9.png

Template:STRUCTURE 3lu9

Contents

Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1

Template:ABSTRACT PUBMED 20236938

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

3LU9 is a 6 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Gandhi PS, Chen Z, Di Cera E. Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1. J Biol Chem. 2010 May 14;285(20):15393-8. Epub 2010 Mar 17. PMID:20236938 doi:10.1074/jbc.M110.115337
  • Pineda AO, Carrell CJ, Bush LA, Prasad S, Caccia S, Chen ZW, Mathews FS, Di Cera E. Molecular dissection of Na+ binding to thrombin. J Biol Chem. 2004 Jul 23;279(30):31842-53. Epub 2004 May 19. PMID:15152000 doi:http://dx.doi.org/10.1074/jbc.M401756200

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