1w7x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1w7x.gif|left|200px]]<br />
+
[[Image:1w7x.jpg|left|200px]]<br /><applet load="1w7x" size="450" color="white" frame="true" align="right" spinBox="true"
-
<applet load="1w7x" size="450" color="white" frame="true" align="right" spinBox="true"
+
caption="1w7x, resolution 1.80&Aring;" />
caption="1w7x, resolution 1.80&Aring;" />
'''FACTOR7- 413 COMPLEX'''<br />
'''FACTOR7- 413 COMPLEX'''<br />
Line 11: Line 10:
==About this Structure==
==About this Structure==
-
1W7X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA, SO4, 413 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W7X OCA].
+
1W7X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA, SO4, 413 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] Known structural/functional Site: <scene name='pdbsite=AC1:So4 Binding Site For Chain H'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W7X OCA].
==Reference==
==Reference==
Line 40: Line 39:
[[Category: serine protease]]
[[Category: serine protease]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:47:42 2007''
+
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:33:43 2007''

Revision as of 16:23, 18 December 2007

Image:1w7x.jpg

1w7x, resolution 1.80Å

Drag the structure with the mouse to rotate

FACTOR7- 413 COMPLEX

Contents

Overview

We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere, with the coagulation cascade by selective inhibition of the extrinsic, pathway.

Disease

Known diseases associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this Structure

1W7X is a Protein complex structure of sequences from Homo sapiens with CA, SO4, 413 and GOL as ligands. Active as Coagulation factor VIIa, with EC number 3.4.21.21 Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors., Zbinden KG, Obst-Sander U, Hilpert K, Kuhne H, Banner DW, Bohm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lave T, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. Epub 2005 Oct 4. PMID:16213138

Page seeded by OCA on Tue Dec 18 18:33:43 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1w7x"
Personal tools