1w8k
From Proteopedia
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| - | [[Image:1w8k.gif|left|200px]]<br /> | + | [[Image:1w8k.gif|left|200px]]<br /><applet load="1w8k" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1w8k" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1w8k, resolution 1.80Å" /> | caption="1w8k, resolution 1.80Å" /> | ||
'''CRYSTAL STRUCTURE OF APICAL MEMBRANE ANTIGEN 1 FROM PLASMODIUM VIVAX'''<br /> | '''CRYSTAL STRUCTURE OF APICAL MEMBRANE ANTIGEN 1 FROM PLASMODIUM VIVAX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1W8K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax] with IMD as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 1W8K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax] with IMD as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Imd Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W8K OCA]. |
==Reference== | ==Reference== | ||
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[[Category: plasmodium antigen]] | [[Category: plasmodium antigen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:34:28 2007'' |
Revision as of 16:24, 18 December 2007
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CRYSTAL STRUCTURE OF APICAL MEMBRANE ANTIGEN 1 FROM PLASMODIUM VIVAX
Overview
Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine, candidate. The protein is essential for host-cell invasion, but its, molecular function is unknown. The crystal structure of the three domains, comprising the ectoplasmic region of the antigen from P. vivax, solved at, 1.8 angstrom resolution, shows that domains I and II belong to the PAN, motif, which defines a superfamily of protein folds implicated in receptor, binding. We also mapped the epitope of an invasion-inhibitory monoclonal, antibody specific for the P. falciparum ortholog and modeled this to the, structure. The location of the epitope and current knowledge on, structure-function correlations for PAN domains together suggest a, receptor-binding role during invasion in which domain II plays a critical, part. These results are likely to aid vaccine and drug design.
About this Structure
1W8K is a Single protein structure of sequence from Plasmodium vivax with IMD as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of the malaria vaccine candidate apical membrane antigen 1., Pizarro JC, Vulliez-Le Normand B, Chesne-Seck ML, Collins CR, Withers-Martinez C, Hackett F, Blackman MJ, Faber BW, Remarque EJ, Kocken CH, Thomas AW, Bentley GA, Science. 2005 Apr 15;308(5720):408-11. Epub 2005 Feb 24. PMID:15731407
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