3i25

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3i25.jpg|left|200px]]
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The entry 3i25 is ON HOLD until Paper Publication
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{{STRUCTURE_3i25| PDB=3i25 | SCENE= }}
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Authors: Lindberg, J.D., Borkakoti, N., Nystrom, S.
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===Potent Beta-Secretase 1 hydroxyethylene Inhibitor===
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Description: Potent Beta-Secretase 1 hydroxyethylene Inhibitor
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 15 08:29:16 2009''
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{{ABSTRACT_PUBMED_20122837}}
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==About this Structure==
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3I25 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I25 OCA].
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==Reference==
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<ref group="xtra">PMID:20122837</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Borkakoti, N.]]
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[[Category: Lindberg, J D.]]
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[[Category: Nystrom, S.]]
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[[Category: Alternative splicing]]
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[[Category: Aspartyl protease]]
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[[Category: Bace]]
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[[Category: Beta-secretase]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Membrane]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Transmembrane]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:34:50 2010''

Revision as of 04:30, 2 June 2010

Template:STRUCTURE 3i25

Potent Beta-Secretase 1 hydroxyethylene Inhibitor

Template:ABSTRACT PUBMED 20122837

About this Structure

3I25 is a 3 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bjorklund C, Adolfsson H, Jansson K, Lindberg J, Vrang L, Hallberg A, Rosenquist S, Samuelsson B. Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core. Bioorg Med Chem. 2010 Feb 15;18(4):1711-23. Epub 2010 Jan 11. PMID:20122837 doi:10.1016/j.bmc.2009.12.051

Page seeded by OCA on Wed Jun 2 08:34:50 2010

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