1avn
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1AVN is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN, HG, AZI and HSM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ | + | 1AVN is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN, HG, AZI and HSM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]]. Structure known Active Site: ZN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AVN OCA]]. |
==Reference== | ==Reference== | ||
Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine., Briganti F, Mangani S, Orioli P, Scozzafava A, Vernaglione G, Supuran CT, Biochemistry. 1997 Aug 26;36(34):10384-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9265618 9265618] | Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine., Briganti F, Mangani S, Orioli P, Scozzafava A, Vernaglione G, Supuran CT, Biochemistry. 1997 Aug 26;36(34):10384-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9265618 9265618] | ||
| + | [[Category: Carbonate dehydratase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: oxo-acid]] | [[Category: oxo-acid]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:42:26 2007'' |
Revision as of 08:37, 30 October 2007
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HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR
Overview
The interaction of native and Co(II)-substituted isozymes I and II of, carbonic anhydrase (CA) with histamine, a well-known activator, was, investigated kinetically, spectroscopically, and X-ray, crystallographically. This activator is of the noncompetitive type with, 4-nitrophenyl acetate and CO2 as substrates for both HCA I and HCA II. The, electronic spectrum of the adduct of Co(II)-HCA II with histamine is, similar to the spectrum of the Co(II)-HCA II-phenol adduct, being only, slightly different from that of the uncomplexed enzyme. This is the first, spectroscopic evidence that the activator molecule binds within the active, site, but not directly to the metal ion. X-ray crystallographic data for, the adduct of HCA II with histamine showed that the activator molecule is, bound at the ... [(full description)]
About this Structure
1AVN is a [Single protein] structure of sequence from [Homo sapiens] with ZN, HG, AZI and HSM as [ligands]. Active as [Carbonate dehydratase], with EC number [4.2.1.1]. Structure known Active Site: ZN. Full crystallographic information is available from [OCA].
Reference
Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine., Briganti F, Mangani S, Orioli P, Scozzafava A, Vernaglione G, Supuran CT, Biochemistry. 1997 Aug 26;36(34):10384-92. PMID:9265618
Page seeded by OCA on Tue Oct 30 10:42:26 2007
Categories: Carbonate dehydratase | Homo sapiens | Single protein | Briganti, F. | Mangani, S. | Orioli, P. | Scozzafava, A. | Supuran, C.T. | Vernaglione, G. | AZI | HG | HSM | ZN | Lyase | Oxo-acid
