2bgd
From Proteopedia
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| - | [[Image:2bgd.gif|left|200px]]<br /> | + | [[Image:2bgd.gif|left|200px]]<br /><applet load="2bgd" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2bgd" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2bgd, resolution 2.40Å" /> | caption="2bgd, resolution 2.40Å" /> | ||
'''STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS'''<br /> | '''STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BGD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CL, PO4, NA and T1D as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] | + | 2BGD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CL, PO4, NA and T1D as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Known structural/functional Site: <scene name='pdbsite=AC1:Po4 Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BGD OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein tyrosine phosphatase]] | [[Category: protein tyrosine phosphatase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:45:54 2007'' |
Revision as of 16:36, 18 December 2007
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STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS
Contents |
Overview
Using structure-based design, a new class of inhibitors of protein, tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the, 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.
Disease
Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[176885], Insulin resistance, susceptibility to OMIM:[176885]
About this Structure
2BGD is a Single protein structure of sequence from Homo sapiens with CL, PO4, NA and T1D as ligands. Active as Protein-tyrosine-phosphatase, with EC number 3.1.3.48 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure-based design of protein tyrosine phosphatase-1B inhibitors., Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J, Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. PMID:15863305
Page seeded by OCA on Tue Dec 18 18:45:54 2007
Categories: Homo sapiens | Protein-tyrosine-phosphatase | Single protein | Black, E. | Breed, J. | Breeze, A.L. | Embrey, K. | Garcia, R. | Gero, T.W. | Godfrey, L. | Kenny, P.W. | Minshull, C.A. | Morley, A.D. | Pannifer, A.D. | Read, J. | Rees, A. | Russell, D.J. | Toader, D. | Tucker, J. | CL | NA | PO4 | T1D | 1 | 1-dioxide template | 2 | 5-thiadiazolidin-3-one-1 | Hydrolase | Protein tyrosine phosphatase
