2bj6
From Proteopedia
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| - | [[Image:2bj6.gif|left|200px]]<br /> | + | [[Image:2bj6.gif|left|200px]]<br /><applet load="2bj6" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2bj6" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2bj6, resolution 2.60Å" /> | caption="2bj6, resolution 2.60Å" /> | ||
'''CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID'''<br /> | '''CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BJ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 2BJ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:So4 Binding Site For Chain G'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BJ6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: rna]] | [[Category: rna]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:49:04 2007'' |
Revision as of 16:39, 18 December 2007
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CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID
Overview
The crystal structure of a decameric HNA/RNA (HNA =, 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the, RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid, duplex between a naturally occurring nucleic acid and a strand, which is, fully modified to contain a six-membered ring instead of ribose. The, presence of four duplex helices in the asymmetric unit allows for a, detailed discussion of hydration, which revealed a tighter spinelike, backbone hydration for the HNA- than for the RNA-strands. The reinforced, backbone hydration is suggested to contribute significantly to the, exceptional stability of HNA-containing duplexes and might be one of the, causes for the evolutionary preference for ribose-derived nucleic acids.
About this Structure
2BJ6 is a Single protein structure of sequence from [1] with SO4 as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid., Maier T, Przylas I, Strater N, Herdewijn P, Saenger W, J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:15740130
Page seeded by OCA on Tue Dec 18 18:49:04 2007
Categories: Single protein | Herdewijn, P. | Maier, T. | Przylas, I. | Saenger, W. | Straeter, N. | SO4 | Antisense | Backbone modification | Dna | Duplex | Hexitol nucleic acid | Hna | Hybrid | Modified nucleic acid | Rna
