2bjn
From Proteopedia
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| - | [[Image:2bjn.gif|left|200px]]<br /> | + | [[Image:2bjn.gif|left|200px]]<br /><applet load="2bjn" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2bjn" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2bjn, resolution 1.70Å" /> | caption="2bjn, resolution 1.70Å" /> | ||
'''X-RAY STRUCTURE OF HUMAN TPC6'''<br /> | '''X-RAY STRUCTURE OF HUMAN TPC6'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BJN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 2BJN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BJN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: trapp complex]] | [[Category: trapp complex]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:49:36 2007'' |
Revision as of 16:39, 18 December 2007
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X-RAY STRUCTURE OF HUMAN TPC6
Overview
The TRAPP (transport protein particle) complexes are tethering complexes, that have an important role at the different steps of vesicle transport., Recently, the crystal structures of the TRAPP subunits SEDL and BET3 have, been determined, and we present here the 1.7 Angstroms crystal structure, of human TPC6, a third TRAPP subunit. The protein adopts an, alpha/beta-plait topology and forms a dimer. In spite of low sequence, similarity, the structure of TPC6 strikingly resembles that of BET3. The, similarity is especially prominent at the dimerization interfaces of the, proteins. This suggests heterodimerization of TPC6 and BET3, which is, shown by in vitro and in vivo association studies. Together with TPC5, another TRAPP subunit, TPC6 and BET3 are supposed to constitute a family, of paralogous proteins with closely similar three-dimensional structures, but little sequence similarity among its members.
About this Structure
2BJN is a Single protein structure of sequence from Homo sapiens with SO4 and GOL as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The structure of the TRAPP subunit TPC6 suggests a model for a TRAPP subcomplex., Kummel D, Muller JJ, Roske Y, Misselwitz R, Bussow K, Heinemann U, EMBO Rep. 2005 Aug;6(8):787-93. PMID:16025134
Page seeded by OCA on Tue Dec 18 18:49:36 2007
Categories: Homo sapiens | Single protein | Bussow, K. | Heinemann, U. | Kummel, D. | Misselwitz, R. | Mueller, J.J. | Roske, Y. | GOL | SO4 | Tethering | Tpc6 | Transport protein | Trapp complex
