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2bks
From Proteopedia
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| - | [[Image:2bks.gif|left|200px]]<br /> | + | [[Image:2bks.gif|left|200px]]<br /><applet load="2bks" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2bks" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2bks, resolution 2.2Å" /> | caption="2bks, resolution 2.2Å" /> | ||
'''CRYSTAL STRUCTURE OF RENIN-PF00074777 COMPLEX'''<br /> | '''CRYSTAL STRUCTURE OF RENIN-PF00074777 COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BKS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PZ1 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] | + | 2BKS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PZ1 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] Known structural/functional Site: <scene name='pdbsite=AC1:Pz1 Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BKS OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:50:26 2007'' |
Revision as of 16:40, 18 December 2007
|
CRYSTAL STRUCTURE OF RENIN-PF00074777 COMPLEX
Contents |
Overview
We have found that both enantiomeric configurations of the, 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin, inhibition activity and similar SAR patterns. This enantiomeric, flexibility is in contrast to a previously reported, 3-alkoxymethyl-4-arylpiperidine scaffold.
Disease
Known diseases associated with this structure: Hyperproreninemia OMIM:[179820], Renal tubular dysgenesis OMIM:[179820]
About this Structure
2BKS is a Single protein structure of sequence from Homo sapiens with PZ1 as ligand. Active as Renin, with EC number 3.4.23.15 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:15837327
Page seeded by OCA on Tue Dec 18 18:50:26 2007
Categories: Homo sapiens | Renin | Single protein | Bryant, J.W. | Clay, E.H. | Edmunds, J.J. | Holsworth, D.D. | Jalaie, M. | Powell, N.A. | Ryan, J.M. | Zhang, E. | PZ1 | Aspartic proteinase | Aspartyl protease | Glycoprotein | Hydrolase | Plasma | Polymorphism | Signal | Zymogen
