User:Cynthia Pruss/Sandbox 1
From Proteopedia
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<applet load='3gxb' size='400' frame='true' align='right' caption='VWF A2 Domain PDB ID:3GXB (Zhang et al)' /> | <applet load='3gxb' size='400' frame='true' align='right' caption='VWF A2 Domain PDB ID:3GXB (Zhang et al)' /> | ||
| - | This is the crystal structure of the VWF A2 domain, elucidated by Zhang, et al | + | This is the crystal structure of the VWF A2 domain, elucidated by Zhang, et al. |
Von Willebrand factor (VWF) is a large multimeric glycoprotein with a critical role in maintaining hemostasis. VWF serves as the carrier protein for the plasma coagulation protein factor VIII (FVIII) and promotes platelet adhesion and aggregation at the sites of vascular damage.<ref>PMID:9759493<ref> The hemostatic potential of VWF greatly increases with the multimer size, which is tightly regulated in vivo by the metalloprotease ADAMTS13.<ref>PMID:8767102<ref><ref>PMID:12393399<ref><ref>PMID:11557746<ref> | Von Willebrand factor (VWF) is a large multimeric glycoprotein with a critical role in maintaining hemostasis. VWF serves as the carrier protein for the plasma coagulation protein factor VIII (FVIII) and promotes platelet adhesion and aggregation at the sites of vascular damage.<ref>PMID:9759493<ref> The hemostatic potential of VWF greatly increases with the multimer size, which is tightly regulated in vivo by the metalloprotease ADAMTS13.<ref>PMID:8767102<ref><ref>PMID:12393399<ref><ref>PMID:11557746<ref> | ||
Revision as of 19:09, 15 June 2010
Von Willebrand Factor A2 Domain
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This is the crystal structure of the VWF A2 domain, elucidated by Zhang, et al.
Von Willebrand factor (VWF) is a large multimeric glycoprotein with a critical role in maintaining hemostasis. VWF serves as the carrier protein for the plasma coagulation protein factor VIII (FVIII) and promotes platelet adhesion and aggregation at the sites of vascular damage.[1]
