2bnl
From Proteopedia
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| - | [[Image:2bnl.gif|left|200px]]<br /> | + | [[Image:2bnl.gif|left|200px]]<br /><applet load="2bnl" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2bnl" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2bnl, resolution 2.00Å" /> | caption="2bnl, resolution 2.00Å" /> | ||
'''THE STRUCTURE OF THE N-TERMINAL DOMAIN OF RSBR'''<br /> | '''THE STRUCTURE OF THE N-TERMINAL DOMAIN OF RSBR'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BNL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 2BNL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Na Binding Site For Chain F'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BNL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: stress response]] | [[Category: stress response]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:53:18 2007'' |
Revision as of 16:43, 18 December 2007
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THE STRUCTURE OF THE N-TERMINAL DOMAIN OF RSBR
Overview
RsbR is a regulator of sigma(B), the RNA polymerase sigma factor subunit, responsible for transcribing the general stress response genes when, environmental stress is imposed on Bacillus subtilis. The C-terminal, domain of RsbR and its paralogues is a substrate for the kinase function, of another sigma(B) regulator, RsbT, but the amino acid sequence of the, N-terminal domain of RsbR does not reveal any obvious biochemical, function. RsbR, its paralogues, and other regulators of sigma(B), including RsbS and RsbT, form large signaling complexes, called, stressosomes. We have determined and present here the crystal structure of, the N-terminal domain of RsbR. Unexpectedly, this structure belongs to the, globin fold superfamily, but there is no bound cofactor. The globin domain, from globin-coupled sensory systems replaces the N-terminal domain of RsbR, in some bacteria, indicating a common genetic ancestry for RsbR and the, globin family. We suggest that the globin fold has been "recycled" in RsbR, and that one more activity can be included in the repertoire of globin, functions, namely the ability to bind signaling macromolecules such as, RsbT.
About this Structure
2BNL is a Single protein structure of sequence from Bacillus subtilis with NA as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of a nonheme globin in environmental stress signaling., Murray JW, Delumeau O, Lewis RJ, Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17320-5. Epub 2005 Nov 21. PMID:16301540
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