2bsm
From Proteopedia
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| - | [[Image:2bsm.gif|left|200px]]<br /> | + | [[Image:2bsm.gif|left|200px]]<br /><applet load="2bsm" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2bsm" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2bsm, resolution 2.05Å" /> | caption="2bsm, resolution 2.05Å" /> | ||
'''NOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN'''<br /> | '''NOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BSM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with BSM as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 2BSM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with BSM as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Bsm Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BSM OCA]. |
==Reference== | ==Reference== | ||
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[[Category: pu3]] | [[Category: pu3]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:57:33 2007'' |
Revision as of 16:47, 18 December 2007
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NOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN
Overview
The crystal structure of a previously reported screening hit 1 (CCT018159), bound to the N terminal domain of molecular chaperone Hsp90 has been used, to design 5-amide analogues. These exhibit enhanced potency against the, target in binding and functional assays with accompanying appropriate, cellular pharmacodynamic changes. Compound 11 (VER-49009) compares, favorably with the clinically evaluated 17-AAG.
About this Structure
2BSM is a Single protein structure of sequence from Homo sapiens with BSM as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design., Dymock BW, Barril X, Brough PA, Cansfield JE, Massey A, McDonald E, Hubbard RE, Surgenor A, Roughley SD, Webb P, Workman P, Wright L, Drysdale MJ, J Med Chem. 2005 Jun 30;48(13):4212-5. PMID:15974572
Page seeded by OCA on Tue Dec 18 18:57:33 2007
Categories: Homo sapiens | Single protein | Barril, X. | Brough, P.A. | Cansfield, J.E. | Drysdale, M.J. | Dymock, B.W. | Hubbard, R.E. | Massey, A. | Mcdonald, E. | Roughley, S.D. | Surgenor, A. | Webb, P. | Workman, P. | Wright, L. | BSM | Atp-binding | Atpase | Chaperone | Heat shock | Hsp90 | Pu3
