2btq
From Proteopedia
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| - | [[Image:2btq.gif|left|200px]]<br /> | + | [[Image:2btq.gif|left|200px]]<br /><applet load="2btq" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2btq" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2btq, resolution 3.2Å" /> | caption="2btq, resolution 3.2Å" /> | ||
'''STRUCTURE OF BTUBAB HETERODIMER FROM PROSTHECOBACTER DEJONGEII'''<br /> | '''STRUCTURE OF BTUBAB HETERODIMER FROM PROSTHECOBACTER DEJONGEII'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BTQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Prosthecobacter_dejongeii Prosthecobacter dejongeii] with SO4 and GDP as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 2BTQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Prosthecobacter_dejongeii Prosthecobacter dejongeii] with SO4 and GDP as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:So4 Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BTQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: verrucomicrobia]] | [[Category: verrucomicrobia]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:58:14 2007'' |
Revision as of 16:48, 18 December 2007
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STRUCTURE OF BTUBAB HETERODIMER FROM PROSTHECOBACTER DEJONGEII
Overview
alphabeta-Tubulin heterodimers, from which the microtubules of the, cytoskeleton are built, have a complex chaperone-dependent folding, pathway. They are thought to be unique to eukaryotes, whereas the, homologue FtsZ can be found in bacteria. The exceptions are BtubA and, BtubB from Prosthecobacter, which have higher sequence homology to, eukaryotic tubulin than to FtsZ. Here we show that some of their, properties are different from tubulin, such as weak dimerization and, chaperone-independent folding. However, their structure is strikingly, similar to tubulin including surface loops, and BtubA/B form tubulin-like, protofilaments. Presumably, BtubA/B were transferred from a eukaryotic, cell by horizontal gene transfer because their high degree of similarity, to eukaryotic genes is unique within the Prosthecobacter genome.
About this Structure
2BTQ is a Protein complex structure of sequences from Prosthecobacter dejongeii with SO4 and GDP as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of bacterial tubulin BtubA/B: evidence for horizontal gene transfer., Schlieper D, Oliva MA, Andreu JM, Lowe J, Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9170-5. Epub 2005 Jun 20. PMID:15967998
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