2xf0

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'''Unreleased structure'''
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{{Seed}}
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[[Image:2xf0.jpg|left|200px]]
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The entry 2xf0 is ON HOLD until Paper Publication
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{{STRUCTURE_2xf0| PDB=2xf0 | SCENE= }}
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Authors: Matthews, T.P., McHardy, T., Klair, S., Boxall, K., Fisher, M., Cherry, M., Allen, C.E., Addison, G.J., Ellard, J., Aherne, G.W., Westwood, I.M., vanMontfort, R., Garrett, M.D., Reader, J.C., Collins, I.
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===CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS===
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Description: Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:26:32 2010''
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{{ABSTRACT_PUBMED_20561787}}
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==About this Structure==
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2XF0 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XF0 OCA].
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==Reference==
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<ref group="xtra">PMID:20561787</ref><ref group="xtra">PMID:19572549</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Addison, G J.]]
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[[Category: Aherne, G W.]]
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[[Category: Allen, C E.]]
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[[Category: Boxall, K.]]
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[[Category: Cherry, M.]]
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[[Category: Collins, I.]]
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[[Category: Ellard, J.]]
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[[Category: Fisher, M.]]
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[[Category: Garrett, M D.]]
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[[Category: Klair, S.]]
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[[Category: Matthews, T P.]]
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[[Category: Mchardy, T.]]
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[[Category: Montfort, R Van.]]
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[[Category: Reader, J C.]]
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[[Category: Westwood, I M.]]
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[[Category: Cell cycle]]
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[[Category: Dna repair]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:45:16 2010''

Revision as of 09:39, 30 June 2010

Image:2xf0.jpg

Template:STRUCTURE 2xf0

CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS

Template:ABSTRACT PUBMED 20561787

About this Structure

2XF0 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Matthews TP, McHardy T, Klair S, Boxall K, Fisher M, Cherry M, Allen CE, Addison GJ, Ellard J, Aherne GW, Westwood IM, van Montfort R, Garrett MD, Reader JC, Collins I. Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4045-9. Epub 2010 May 27. PMID:20561787 doi:10.1016/j.bmcl.2010.05.096
  • Matthews TP, Klair S, Burns S, Boxall K, Cherry M, Fisher M, Westwood IM, Walton MI, McHardy T, Cheung KM, Van Montfort R, Williams D, Aherne GW, Garrett MD, Reader J, Collins I. Identification of inhibitors of checkpoint kinase 1 through template screening. J Med Chem. 2009 Aug 13;52(15):4810-9. PMID:19572549 doi:10.1021/jm900314j

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