1hkv
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1HKV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with LYS and PLP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ | + | 1HKV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with LYS and PLP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Diaminopimelate_decarboxylase Diaminopimelate decarboxylase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.20 4.1.1.20]]. Structure known Active Site: PLA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HKV OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis., Gokulan K, Rupp B, Pavelka MS Jr, Jacobs WR Jr, Sacchettini JC, J Biol Chem. 2003 May 16;278(20):18588-96. Epub 2003 Mar 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12637582 12637582] | Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis., Gokulan K, Rupp B, Pavelka MS Jr, Jacobs WR Jr, Sacchettini JC, J Biol Chem. 2003 May 16;278(20):18588-96. Epub 2003 Mar 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12637582 12637582] | ||
| + | [[Category: Diaminopimelate decarboxylase]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: tbsgc]] | [[Category: tbsgc]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:46:56 2007'' |
Revision as of 08:42, 30 October 2007
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MYCOBACTERIUM DIAMINOPIMELATE DICARBOXYLASE (LYSA)
Overview
The Mycobacterium tuberculosis lysA gene encodes the enzyme, meso-diaminopimelate decarboxylase (DAPDC), a pyridoxal-5'-phosphate, (PLP)-dependent enzyme. The enzyme catalyzes the final step in the lysine, biosynthetic pathway converting meso-diaminopimelic acid (DAP) to, l-lysine. The lysA gene of M. tuberculosis H37Rv has been established as, essential for bacterial survival in immunocompromised mice, demonstrating, that de novo biosynthesis of lysine is essential for in vivo viability., Drugs targeted against DAPDC could be efficient anti-tuberculosis drugs, and the three-dimensional structure of DAPDC from M. tuberculosis, complexed with reaction product lysine and the ternary complex with PLP, and lysine in the active site has been determined. The first structure of, a DAPDC confirms ... [(full description)]
About this Structure
1HKV is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with LYS and PLP as [ligands]. Active as [Diaminopimelate decarboxylase], with EC number [4.1.1.20]. Structure known Active Site: PLA. Full crystallographic information is available from [OCA].
Reference
Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis., Gokulan K, Rupp B, Pavelka MS Jr, Jacobs WR Jr, Sacchettini JC, J Biol Chem. 2003 May 16;278(20):18588-96. Epub 2003 Mar 10. PMID:12637582
Page seeded by OCA on Tue Oct 30 10:46:56 2007
Categories: Diaminopimelate decarboxylase | Mycobacterium tuberculosis | Single protein | Gokulan, K. | Junior, M.S.Pavelka. | Junior, W.R.Jacobs. | Rupp, B. | Sacchettini, J.C. | TBSGC, TB.Structural.Genomics.Consortium. | LYS | PLP | Dapdc | Decarboxylase | Diaminopimelate | Lyase | Lysine pathway | Lysine synthetic pathway | Mycbacterium tuberculosis | Plp | Protein structure initiative | Psi | Pyridoxal phosphate | Tb | Tb structural genomics consortium | Tbsgc
