2cg4
From Proteopedia
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| - | [[Image:2cg4.gif|left|200px]]<br /> | + | [[Image:2cg4.gif|left|200px]]<br /><applet load="2cg4" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2cg4" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2cg4, resolution 2.40Å" /> | caption="2cg4, resolution 2.40Å" /> | ||
'''STRUCTURE OF E.COLI ASNC'''<br /> | '''STRUCTURE OF E.COLI ASNC'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2CG4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with MG and ASN as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 2CG4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with MG and ASN as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Mg Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transcription regulation]] | [[Category: transcription regulation]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:21:41 2007'' |
Revision as of 17:11, 18 December 2007
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STRUCTURE OF E.COLI ASNC
Overview
The Lrp/AsnC family of transcriptional regulatory proteins is found in, both archaea and bacteria. Members of the family influence cellular, metabolism in both a global (Lrp) and specific (AsnC) manner, often in, response to exogenous amino acid effectors. In the present study we have, determined both the first bacterial and the highest resolution structures, for members of the family. Escherichia coli AsnC is a specific gene, regulator whose activity is triggered by asparagine binding. Bacillus, subtilis LrpC is a global regulator involved in chromosome condensation., Our AsnC-asparagine structure is the first for a regulator-effector, complex and is revealed as an octameric disc. Key ligand recognition, residues are identified together with a route for ligand access. The LrpC, structure reveals a stable octamer supportive of a topological role in, dynamic DNA packaging. The structures yield significant clues to the, functionality of Lrp/AsnC-type regulators with respect to ligand binding, and oligomerization states as well as to their role in specific and global, DNA regulation.
About this Structure
2CG4 is a Single protein structure of sequence from Escherichia coli with MG and ASN as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family., Thaw P, Sedelnikova SE, Muranova T, Wiese S, Ayora S, Alonso JC, Brinkman AB, Akerboom J, van der Oost J, Rafferty JB, Nucleic Acids Res. 2006 Mar 9;34(5):1439-49. Print 2006. PMID:16528101
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Categories: Escherichia coli | Single protein | Akerboom, J. | Alonso, J.C. | Ayora, S. | Brinkman, A.B. | Muranova, T. | Oost, J.Van.Der. | Rafferty, J.B. | Sedelnikova, S.E. | Thaw, P. | Wiese, S. | ASN | MG | Asnc | Dna binding | Dna-binding | Ffrp | Lrp family | Transcription | Transcription regulation
