2cki
From Proteopedia
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| - | [[Image:2cki.gif|left|200px]]<br /> | + | [[Image:2cki.gif|left|200px]]<br /><applet load="2cki" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2cki" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2cki, resolution 1.70Å" /> | caption="2cki, resolution 1.70Å" /> | ||
'''STRUCTURE OF ULILYSIN, A MEMBER OF THE PAPPALYSIN FAMILY OF METZINCIN METALLOENDOPEPTIDASES.'''<br /> | '''STRUCTURE OF ULILYSIN, A MEMBER OF THE PAPPALYSIN FAMILY OF METZINCIN METALLOENDOPEPTIDASES.'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2CKI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans] with CA, ZN, ARG and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 2CKI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans] with CA, ZN, ARG and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:VAL Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: pappalysin]] | [[Category: pappalysin]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:26:15 2007'' |
Revision as of 17:16, 18 December 2007
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STRUCTURE OF ULILYSIN, A MEMBER OF THE PAPPALYSIN FAMILY OF METZINCIN METALLOENDOPEPTIDASES.
Overview
The metzincin clan encompasses several families of zinc-dependent, metalloproteases with proven function both in physiology and pathology., They act either as broad spectrum protein degraders or as sheddases, operating through limited proteolysis. Among the structurally, uncharacterized metzincin families are the pappalysins, of which the most, thoroughly studied member is human pregnancy-associated plasma protein A, (PAPP-A), a heavily glycosylated 170-kDa multidomain protein specifically, cleaving insulin-like growth factor (IGF)-binding proteins (IGFBPs)., Proulilysin is a 38-kDa archaeal protein that shares sequence similarity, with PAPP-A but encompasses only the pro-domain and the catalytic domain., It undergoes calcium-mediated autolytic activation, and the mature protein, adopts a three-dimensional structure with two subdomains separated by an, active site cleft containing the catalytic zinc ion. This structure is, reminiscent of human members of the adamalysin/ADAMs (a disintegrin and a, metalloprotease) family of metzincins. A bound dipeptide yields, information on the substrate specificity of ulilysin, which specifically, hydrolyzes IGFBP-2 to -6, insulin, and extracellular matrix proteins but, not IGFBP-1 or IGF-II. Accordingly, ulilysin has higher proteolytic, efficiency and a broader substrate specificity than human PAPP-A. The, structure of ulilysin represents a prototype for the catalytic domain of, pappalysins.
About this Structure
2CKI is a Single protein structure of sequence from Methanosarcina acetivorans with CA, ZN, ARG and GOL as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Molecular analysis of ulilysin, the structural prototype of a new family of metzincin metalloproteases., Tallant C, Garcia-Castellanos R, Seco J, Baumann U, Gomis-Ruth FX, J Biol Chem. 2006 Jun 30;281(26):17920-8. Epub 2006 Apr 20. PMID:16627477
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Categories: Methanosarcina acetivorans | Single protein | Baumann, U. | Garcia-Castellanos, R. | Gomis-Ruth, F.X. | Seco, J. | Tallant, C. | ARG | CA | GOL | ZN | Cancer | Hydrolase | Hypothetical protein | Igf | Igfbp protease | Metalloprotease | Metzincin | Pappalysin
