Superoxide Dismutase
From Proteopedia
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===Metal-free apo SOD=== | ===Metal-free apo SOD=== | ||
- | [[3lii]] – hAChE - recombinant human <br /> | ||
+ | [[3hog]] – SOD – tomato <br /> | ||
+ | [[1p7g]] – SOD – Pyrobaculum aerophilum <br /> | ||
- | ===AChE inhibitors (In Different Languages)=== | ||
- | [[1eve]] AChE-Aricept complex, [[1eve (Arabic)]], [[1eve (Chinese)]], [[1eve (Italian)]], [[1eve (Russian)]], [[1eve (Spanish)]], [[1eve (Turkish)]] <br /> | ||
- | [[1vot]] AChE-Huperzine A complex, [[1vot (Chinese)]] <br /> | ||
- | ===AChE active site inhibitors conjugating at the bottom of the active site gorge=== | ||
- | [[2w9i]] – ''Tc''AChE + methylene blue <br /> | ||
- | [[2wls]] – MosAChE + AMTS13 <br /> | ||
- | [[2vq6]] – ''Tc''AChE + 2-PAM <br /> | ||
- | [[2j3q]] – ''Tc''AChE + Thioflavin T <br /> | ||
- | [[2ha0]] – mAChE + ketoamyltrimethylammonium <br /> | ||
- | [[2h9y]] – mAChE + TMTFA <br /> | ||
- | [[1gpk]], [[1gpn]], [[1vot]] – ''Tc''AChE + huperzine <br /> | ||
- | [[1gqr]] – ''Tc''AChE + rivastigmine <br /> | ||
- | [[1gqs]] – ''Tc''AChE + NAP <br /> | ||
- | [[1e66]] – ''Tc''AChE + huprine <br /> | ||
- | [[1dx4]], [[1qon]] – ''Dm''AChE + tacrine derivative <br /> | ||
- | [[1oce]] – ''Tc''AChE + MF268 <br /> | ||
- | [[1ax9]], [[1ack]] – ''Tc''AChE + edrophonium <br /> | ||
- | [[1amn]] – ''Tc''AChE + TMTFA <br /> | ||
- | [[1acj]] – ''Tc''AChE + tacrine <br /> | ||
- | === | + | ===Cu-Zn-SOD=== |
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- | + | [[2jlp]], [[2v0a]], [[2c9v]], [[2c9u]], [[2c9s]], [[1pu0]], [[1hl5]], [[1sos]], [[1spd]] - hSOD +Zn+Cu - human<br /> | |
- | [[ | + | [[3h2p]], [[3h2q]], [[3h2r]], [[3hff]], [[3gqf]], [[2nnx]], [[1p1v]], [[1oez]] – hSOD (mutant) +Zn<br /> |
- | [[ | + | [[2af2]], [[1kmg]] - hSOD (mutant) +Zn – NMR<br /> |
- | [[ | + | [[1l3n]], [[1dsw]], [[1ba9]] – hSOD (mutant) +Zn+Cu - NMR<br /> |
- | [[ | + | [[1rk7]] - hSOD (mutant) apo – NMR<br /> |
- | [[ | + | [[1ozt]], [[3gzp]], [[3gzq]], [[3ecv]], [[3ecw]], [[2gbu]] - hSOD (mutant) apo<br /> |
- | [[ | + | [[3ecu]], [[3k91]] – hSOD apo<br /> |
- | [[ | + | [[2r27]] - hSOD +Cu<br /> |
- | [[ | + | [[1hl4]] - hSOD +Zn<br /> |
- | [[ | + | [[2wko]], [[3gzo]],[[ 2zkw]], [[2zkx]], [[2zky]], [[3cqp]], [[3cqq]], [[2vr6]], [[2vr7]], [[2vr8]], [[2gbt]], [[2gbv]], [[1uxl]], [[1uxm]], [[1ptz]], [[1ozu]], [[1n18]], [[1n19]], [[1fun]], [[1mfm]], [[1azv]] – hSOD (mutant) +Zn+Cu<br /> |
- | [[ | + | [[3l9e]] - smSOD +Zn – silk moth<br /> |
- | [[ | + | [[3l9y]] - smSOD +Zn+Cu<br /> |
- | [[ | + | [[2wn0]] – YpSOD+Zn+Cu – Yersinia pseudotuberculosis<br /> |
- | [[ | + | [[2wn1]] - YpSOD+Zn+Cu+N3<br /> |
- | [[ | + | [[2z7u]], [[2z7w]], [[2z7y]], [[2z7z]], [[2aeo]], [[1q0e]], [[1e9p]], [[1e9q]], [[1cb4]], [[1cbj]], [[1sxn]], [[1sxa]], [[1sxb]], [[1sxc]], [[1spd]], [[1sda]], [[3sod]], [[2sod]], [[2zow]], [[3hw7]] – cSOD+Zn+Cu - cow<br /> |
- | [[ | + | [[1cob]] – cSOD+Cu+Co<br /> |
+ | [[1sxs]] - cSOD +Zn+Cu+SCN<br /> | ||
+ | [[1sxz]] - cSOD +Zn+Cu+N3<br /> | ||
+ | [[1e9o]] – cSOD+Cu<br /> | ||
+ | [[3f7k]] - ApSOD +Zn+Cu+H2O2 – Alvinella pompejana<br /> | ||
+ | [[3f7l]] - ApSOD +Zn+Cu<br /> | ||
+ | [[2k4w]] – SeSOD (mutant) +Zn+Cu – Salmonella enterica – NMR<br /> | ||
+ | [[1eqw]] - SOD +Zn+Cu – Salmonella typhimurium<br /> | ||
+ | [[3ce1]] - SOD +Zn+Cu – Cryptococcus liquefaciens<br /> | ||
+ | [[2q2l]] - SOD +Zn – Potentilla atrosanguinea<br /> | ||
+ | [[2aqm]] - SOD +Zn+Cu – Brucella abortus<br /> | ||
+ | [[2aps]] - SOD +Zn+Cu – Actinobacillus pleuropneumoniae<br /> | ||
+ | [[2aqn]] - NmSOD +Zn+Cu – Neisseria meningitides<br /> | ||
+ | [[2aqp]], [[2aqq]], [[2aqr]], [[2aqs]], [[2aqt]] – NmSOD (mutant) +Zn+Cu<br /> | ||
+ | [[1z9n]] - HdSOD +Zn+Cu+haem – Haemophilus ducreyi<br /> | ||
+ | [[1z9p]] - HdSOD +Zn+Cu<br /> | ||
+ | [[1to4]], [[1to5]] - SOD +Zn+Cu – Schistosoma mansoni<br /> | ||
+ | [[1pzs]] - MtSOD +Cu – Mycobacterium tuberculosis<br /> | ||
+ | [[1oaj]], [[1bzo]], [[1yai]] - PlSOD +Zn+Cu – Photobacterium leiognathi<br /> | ||
+ | [[1oal]], [[1ib5]], [[1ibb]], [[1ibd]], [[1ibf]], [[1ibh]] – PlSOD (mutant) +Zn+Cu<br /> | ||
+ | [[1f18]], [[1f1a]], [[1f1d]], [[1b4t]] – ySOD (mutant) +Zn+Cu – yeast<br /> | ||
+ | [[1f1g]], [[1b4l]], [[2jcw]], [[1sdy]] - ySOD +Zn+Cu<br /> | ||
+ | [[1yaz]] - ySOD +Zn+Cu+N3<br /> | ||
+ | [[1jk9]] – ySOD+Zn+Cu chaperone for SOD<br /> | ||
+ | [[1eso]] - EcSOD +Zn+Cu - Escherichia coli<br /> | ||
+ | [[1yso]] - EcSOD +Zn+Cu<br /> | ||
+ | [[1srd]] – SOD+MZn+Cu –Spinach<br /> | ||
- | === | + | ===Mn-SOD=== |
- | [[ | + | [[3k9s]] – EcSOD+H2O2 <br /> |
- | [[ | + | [[1d5n]], [[1vew]] - EcSOD+Mn<br /> |
- | [[ | + | [[1mmm]] – EcSOD+Fe<br /> |
- | [[ | + | [[1zlz]], [[1ixb]], [[1ix9]], [[1en4]], [[1en5]], [[1en6]], [[1i08]], [[1i0h]] – EcSOD (mutant)+Mn<br /> |
- | [[ | + | [[3dc5]], [[3dc6]] – SOD+Mn – Caenorhabditis elegans<br /> |
- | [[ | + | [[3bfr]], [[1jcv]] – ySOD+Mn <br /> |
- | [[ | + | [[2qka]], [[2adp]], [[2adq]], [[1xdc]], [[1xil]], [[1n0j]], [[1luv]], [[1msd]] – hSOD+Mn<br /> |
- | [[ | + | [[2qkc]], [[3c3s]], [[3c3t]], [[2p4k]], [[1zsp]], [[1zte]], [[1zuq]], [[2gds]], [[1szx]], [[1pl4]], [[1pm9]], [[1n0n]], [[1luw]], [[1ja8]], [[1em1]], [[1ap5]], [[1ap6]], [[1qnm]], [[1var]] – hSOD (mutant)+Mn<br /> |
- | [[ | + | [[2rcv]] – SOD+Mn – Bacillus subtilis<br /> |
- | [[ | + | [[1xre]], [[1xuq]] – SOD+Mn – Bacillus anthracis<br /> |
- | [[ | + | [[2aw9]], [[2cdy]], [[2ce4]] – DrSOD+Mn – Deinococcus radiodurans<br /> |
- | [[ | + | [[1y67]] – DrSOD+Fe<br /> |
- | [[ | + | [[2a03]] – SOD+Mn+Zn – Plasmodium berghei<br /> |
- | [[ | + | [[1jr9]] - SOD +Zn+Mn – Virgibacillus halodenitrificans<br /> |
- | [[ | + | [[1gv3]] – SOD+Mn – Anabaena<br /> |
- | [[ | + | [[1kkc]] – SOD+Mn – Aspergillus fumigatus<br /> |
- | [[ | + | [[1xso]] – SOD+Mn – Xenopus laevis<br /> |
- | [[ | + | [[1mng]], [[3mds]] – TtSOD+Mn – Thermus thermophilus<br /> |
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- | ===AChE substrate analogues mimicking the binding of the substrate acetylcholine=== | ||
- | [[2ha4]] – mAChE (mutant) + acetylcholine <br /> | ||
- | [[2vja]], [[2vjb]], [[2vjc]], [[2vjd]], [[2cf5]] – ''Tc''AChE + 4-oxo-N,N,N-trimethylpentanaminium <br /> | ||
- | [[2v96]], [[2v97]], [[2v98]], [[2v99]] – ''Tc''AChE + 1-(2-nitrophenyl)-2,2,2-trifluoroethyl-arsenocholine <br /> | ||
- | [[2ha2]] – mAChE + succinylcholine <br /> | ||
- | [[2ha3]] - mAChE + choline <br /> | ||
- | [[2ha5]] – mAChE (mutant) + acetylthiocholine <br /> | ||
- | [[2ha6]] – mAChE (mutant) + succinylthiocholine <br /> | ||
- | [[2ha7]] – mAChE (mutant) + butyrylthiocholine <br /> | ||
- | [[2ch4]], [[2c58]] – ''Tc''AChE + acetylthiocholine <br /> | ||
- | [[2c5g]] – ''Tc''AChE + thiocholine <br /> | ||
- | === | + | ===Fe-SOD=== |
- | [[ | + | [[3js4]] – SOD+Fe – Anaplasma phagocytuphilum<br /> |
- | [[ | + | [[3evk]] – SOD+Mn – Pyrobaculum aerophilum<br /> |
- | [[ | + | [[3esf]] – SOD (mutant)+Fe – Trypanosoma brucei<br /> |
+ | [[2gpc]] – SOD+Fe – Trypanosoma cruzi<br /> | ||
+ | [[3h1s]] – SOD+Fe – Francisella tularensis<br /> | ||
+ | [[2w7w]] – SOD+Fe – Aliivibrio salmonicida<br /> | ||
+ | [[3cei]] – SOD+Fe – Helicobacter pylori<br /> | ||
+ | [[2goj]], [[2bpi]] – PfSOD+Fe – Plasmodium falciparum<br /> | ||
+ | [[2awp]] – SOD+ion – Plasmodium knowlesi<br /> | ||
+ | [[2bkb]], [[2nyb]], [[1za5]] – EcSOD (mutant)+Fe<br /> | ||
+ | [[2cw2]], [[2cw3]] – SOD+Fe – Perkinsus marinus<br /> | ||
+ | [[1wb7]], [[1wb8]] – SOD (mutant)+Fe – Sulfolobus solfataricus<br /> | ||
+ | [[1unf]] – SOD+Fe – Vigna unguiculata<br /> | ||
+ | [[1uer]], [[1ues]], [[1qnn]] – SOD+Fe – Porphyromonas gingivalis<br /> | ||
+ | [[1my6]] – SOD+Fe – Thermosynechococcus elongates<br /> | ||
+ | [[1ma1]] – SOD+Fe – Methanothermobacter thermautotrophicus<br /> | ||
+ | [[1gn2]], [[1gn3]], [[1gn4]], [[1gn6]] – MtSOD (mutant)+Fe<br /> | ||
+ | [[1ids]] – MtSOD+Fe<br /> | ||
+ | [[1dt0]], [[3sdp]] – SOD+Fe – Pseudomonas putida<br /> | ||
+ | [[1b06]] – SOD+Fe – Sulfolobus acidocaldarius<br /> | ||
+ | [[1bs3]] – PfSOD+Fe+F – Propionibacterium freudenreichii<br /> | ||
+ | [[1bsm]], [[1bt8]] – PfSOD+Fe<br /> | ||
+ | [[1ar4]], [[1ar5]] – PfSOD+Mn<br /> | ||
+ | [[1avm]] – PfSOD+Fe+N3<br /> | ||
+ | [[1coj]] – SOD+Fe – Aquifex pyrophilus<br /> | ||
+ | [[1isa]], [[1isb]], [[1isc]] – EcSOD+Fe <br /> | ||
- | + | ===Ni-SOD=== | |
- | + | [[3g4x]], [[3g4z]], [[3g50]], [[1t6u]] – ScSOD (mutant)+Ni – Streptomyces coelicolor<br /> | |
- | + | [[1t6i]], [[1t6q]] – ScSOD apo <br /> | |
- | + | [[1q0d]], [[1q0f]], [[1q0g]], [[1q0k]], [[1q0m]] – SOD+Ni – Streptomyces seoulensis<br /> | |
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Revision as of 09:29, 22 July 2010
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3D Structure of Superoxide Dismutase
Contents |
Antioxidant Enzyme
Superoxide dismutase (SOD) are a group of antioxidant enzymes which catalyze the reaction converting superoxide to oxygen and hydrogen peroxide. SOD uses metals as cofactors and are named accordingly: Cu-Zn-SOD, Cu-SOD, Fe-SOD, Mn-SOD. The image at the right is a dimer of the Superoxide Dismutase with copper and zinc bound metal ions as well as a sulfate ion and acetyl group.
3D Structures of SOD
Metal-free apo SOD
3hog – SOD – tomato
1p7g – SOD – Pyrobaculum aerophilum
Cu-Zn-SOD
2jlp, 2v0a, 2c9v, 2c9u, 2c9s, 1pu0, 1hl5, 1sos, 1spd - hSOD +Zn+Cu - human
3h2p, 3h2q, 3h2r, 3hff, 3gqf, 2nnx, 1p1v, 1oez – hSOD (mutant) +Zn
2af2, 1kmg - hSOD (mutant) +Zn – NMR
1l3n, 1dsw, 1ba9 – hSOD (mutant) +Zn+Cu - NMR
1rk7 - hSOD (mutant) apo – NMR
1ozt, 3gzp, 3gzq, 3ecv, 3ecw, 2gbu - hSOD (mutant) apo
3ecu, 3k91 – hSOD apo
2r27 - hSOD +Cu
1hl4 - hSOD +Zn
2wko, 3gzo, 2zkw, 2zkx, 2zky, 3cqp, 3cqq, 2vr6, 2vr7, 2vr8, 2gbt, 2gbv, 1uxl, 1uxm, 1ptz, 1ozu, 1n18, 1n19, 1fun, 1mfm, 1azv – hSOD (mutant) +Zn+Cu
3l9e - smSOD +Zn – silk moth
3l9y - smSOD +Zn+Cu
2wn0 – YpSOD+Zn+Cu – Yersinia pseudotuberculosis
2wn1 - YpSOD+Zn+Cu+N3
2z7u, 2z7w, 2z7y, 2z7z, 2aeo, 1q0e, 1e9p, 1e9q, 1cb4, 1cbj, 1sxn, 1sxa, 1sxb, 1sxc, 1spd, 1sda, 3sod, 2sod, 2zow, 3hw7 – cSOD+Zn+Cu - cow
1cob – cSOD+Cu+Co
1sxs - cSOD +Zn+Cu+SCN
1sxz - cSOD +Zn+Cu+N3
1e9o – cSOD+Cu
3f7k - ApSOD +Zn+Cu+H2O2 – Alvinella pompejana
3f7l - ApSOD +Zn+Cu
2k4w – SeSOD (mutant) +Zn+Cu – Salmonella enterica – NMR
1eqw - SOD +Zn+Cu – Salmonella typhimurium
3ce1 - SOD +Zn+Cu – Cryptococcus liquefaciens
2q2l - SOD +Zn – Potentilla atrosanguinea
2aqm - SOD +Zn+Cu – Brucella abortus
2aps - SOD +Zn+Cu – Actinobacillus pleuropneumoniae
2aqn - NmSOD +Zn+Cu – Neisseria meningitides
2aqp, 2aqq, 2aqr, 2aqs, 2aqt – NmSOD (mutant) +Zn+Cu
1z9n - HdSOD +Zn+Cu+haem – Haemophilus ducreyi
1z9p - HdSOD +Zn+Cu
1to4, 1to5 - SOD +Zn+Cu – Schistosoma mansoni
1pzs - MtSOD +Cu – Mycobacterium tuberculosis
1oaj, 1bzo, 1yai - PlSOD +Zn+Cu – Photobacterium leiognathi
1oal, 1ib5, 1ibb, 1ibd, 1ibf, 1ibh – PlSOD (mutant) +Zn+Cu
1f18, 1f1a, 1f1d, 1b4t – ySOD (mutant) +Zn+Cu – yeast
1f1g, 1b4l, 2jcw, 1sdy - ySOD +Zn+Cu
1yaz - ySOD +Zn+Cu+N3
1jk9 – ySOD+Zn+Cu chaperone for SOD
1eso - EcSOD +Zn+Cu - Escherichia coli
1yso - EcSOD +Zn+Cu
1srd – SOD+MZn+Cu –Spinach
Mn-SOD
3k9s – EcSOD+H2O2
1d5n, 1vew - EcSOD+Mn
1mmm – EcSOD+Fe
1zlz, 1ixb, 1ix9, 1en4, 1en5, 1en6, 1i08, 1i0h – EcSOD (mutant)+Mn
3dc5, 3dc6 – SOD+Mn – Caenorhabditis elegans
3bfr, 1jcv – ySOD+Mn
2qka, 2adp, 2adq, 1xdc, 1xil, 1n0j, 1luv, 1msd – hSOD+Mn
2qkc, 3c3s, 3c3t, 2p4k, 1zsp, 1zte, 1zuq, 2gds, 1szx, 1pl4, 1pm9, 1n0n, 1luw, 1ja8, 1em1, 1ap5, 1ap6, 1qnm, 1var – hSOD (mutant)+Mn
2rcv – SOD+Mn – Bacillus subtilis
1xre, 1xuq – SOD+Mn – Bacillus anthracis
2aw9, 2cdy, 2ce4 – DrSOD+Mn – Deinococcus radiodurans
1y67 – DrSOD+Fe
2a03 – SOD+Mn+Zn – Plasmodium berghei
1jr9 - SOD +Zn+Mn – Virgibacillus halodenitrificans
1gv3 – SOD+Mn – Anabaena
1kkc – SOD+Mn – Aspergillus fumigatus
1xso – SOD+Mn – Xenopus laevis
1mng, 3mds – TtSOD+Mn – Thermus thermophilus
Fe-SOD
3js4 – SOD+Fe – Anaplasma phagocytuphilum
3evk – SOD+Mn – Pyrobaculum aerophilum
3esf – SOD (mutant)+Fe – Trypanosoma brucei
2gpc – SOD+Fe – Trypanosoma cruzi
3h1s – SOD+Fe – Francisella tularensis
2w7w – SOD+Fe – Aliivibrio salmonicida
3cei – SOD+Fe – Helicobacter pylori
2goj, 2bpi – PfSOD+Fe – Plasmodium falciparum
2awp – SOD+ion – Plasmodium knowlesi
2bkb, 2nyb, 1za5 – EcSOD (mutant)+Fe
2cw2, 2cw3 – SOD+Fe – Perkinsus marinus
1wb7, 1wb8 – SOD (mutant)+Fe – Sulfolobus solfataricus
1unf – SOD+Fe – Vigna unguiculata
1uer, 1ues, 1qnn – SOD+Fe – Porphyromonas gingivalis
1my6 – SOD+Fe – Thermosynechococcus elongates
1ma1 – SOD+Fe – Methanothermobacter thermautotrophicus
1gn2, 1gn3, 1gn4, 1gn6 – MtSOD (mutant)+Fe
1ids – MtSOD+Fe
1dt0, 3sdp – SOD+Fe – Pseudomonas putida
1b06 – SOD+Fe – Sulfolobus acidocaldarius
1bs3 – PfSOD+Fe+F – Propionibacterium freudenreichii
1bsm, 1bt8 – PfSOD+Fe
1ar4, 1ar5 – PfSOD+Mn
1avm – PfSOD+Fe+N3
1coj – SOD+Fe – Aquifex pyrophilus
1isa, 1isb, 1isc – EcSOD+Fe
Ni-SOD
3g4x, 3g4z, 3g50, 1t6u – ScSOD (mutant)+Ni – Streptomyces coelicolor
1t6i, 1t6q – ScSOD apo
1q0d, 1q0f, 1q0g, 1q0k, 1q0m – SOD+Ni – Streptomyces seoulensis
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, David Canner, Alexander Berchansky, Eric Martz, Joel L. Sussman, Jane S. Richardson, Jaime Prilusky