Severin
From Proteopedia
(Difference between revisions)
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[[Image:3fg6.png|left|200px]] | [[Image:3fg6.png|left|200px]] | ||
| - | {{STRUCTURE_3fg6| PDB=3fg6 | SCENE= |CAPTION=Severin, [[3fg6]] }} | + | {{STRUCTURE_3fg6| PDB=3fg6 | SCENE=Severin/Cv/1 |CAPTION=Severin, [[3fg6]] }} |
| - | '''3D Structure of | + | '''3D Structure of Severin''' <br /> |
== Actin Binding Protein == | == Actin Binding Protein == | ||
| - | Severin is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from [[Gelsolin]] (G1-G6). It is named Adseverin and Scinderin as well. | + | Severin is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from [[Gelsolin]] (G1-G6). It is named Adseverin and Scinderin as well. The image at the right is a <scene name='Severin/Cv/2'>octamer</scene> (each monomer is colored in different colors) of the Severin with <scene name='Severin/Cv/3'>calcium ions</scene> (<font color='lime'><b>colored lime</b></font>). |
| + | == 3D Structures of Severin == | ||
[[3fg6]] – Adseverin C-terminal – human<br /> | [[3fg6]] – Adseverin C-terminal – human<br /> | ||
[[1svy]] – Severin domain 2 – ''Dictyostelium discoideum'' <br /> | [[1svy]] – Severin domain 2 – ''Dictyostelium discoideum'' <br /> | ||
[[1svq]] - Severin domain 2 - ''Dictyostelium discoideum'', NMR<br /> | [[1svq]] - Severin domain 2 - ''Dictyostelium discoideum'', NMR<br /> | ||
Revision as of 11:19, 22 July 2010
3D Structure of Severin
Actin Binding Protein
Severin is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from Gelsolin (G1-G6). It is named Adseverin and Scinderin as well. The image at the right is a (each monomer is colored in different colors) of the Severin with (colored lime).
3D Structures of Severin
3fg6 – Adseverin C-terminal – human
1svy – Severin domain 2 – Dictyostelium discoideum
1svq - Severin domain 2 - Dictyostelium discoideum, NMR
