This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Tropomyosin
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1c1g. | + | [[Image:1c1g.png|left|300px]] |
| - | + | ||
{{STRUCTURE_1c1g| PDB=1c1g | SCENE= |CAPTION=Tropomyosin from ''Sus scrofa'', [[1c1g]] }} | {{STRUCTURE_1c1g| PDB=1c1g | SCENE= |CAPTION=Tropomyosin from ''Sus scrofa'', [[1c1g]] }} | ||
Revision as of 12:21, 22 July 2010
| |||||||||
| Tropomyosin from Sus scrofa, 1c1g | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
3D Structure of Tropomyosin
The image at the top is a Tropomyosin from Sus scrofa (1c1g)
Tropomyosin
Tropomyosin (TPM) has a 4-helix coiled dimer structure. It regulates the binding of myosin thus regulating muscle contraction. In its locked conformation it binds troponin T (TnnT) and prevents the binding of myosin to actin. When Ca+ atoms bind to TnnT, the TPM assumes an open conformation and myosin can bind to actin.
3D Structure of Tropomyosin
3mtu, 3mud – cTPM alpha-1 – chicken
1ic2 - cTPM alpha-1 (mutant)
2w49 – cTnnC+cTnnT+cTnnI+cTPM alpha-1+cActin
2z5h – yTPM alpha-1 N-terminal+C-terminal+GNC4+TnnT – yeast
2z5i - yTPM alpha-1 N-terminal+C-terminal+GNC4
2efr, 2efs, 2d3e - rTPM alpha-1 C-terminal+GNC4 – rabbit
1kql - TPM alpha-1 C-terminal+GNC4 - rat
2b9c – TPM mid region – rat
1c1g – TPM – pig
2tma – TPM - model
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Gregory Hoeprich, Jaime Prilusky, David Canner, Joel L. Sussman
