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Gyrase
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(New page: 350px <applet load='3l6v.pdb' size='350' frame='true' align='right' scene="" caption= 'Crystal Structure of the Xanthomonas campestris Gyrase A C-terminal Domain, ...)
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Revision as of 06:50, 23 July 2010
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3D Structure of Gyrase
The image at the left is a Crystal Structure of the Gyrase A C-terminal Domain(3l6v)
Contents |
Gyrase
Gyrase (Gyr) is a type of topoisomerase II in prokaryotes which unwinds double stranded DNA. The DNA Gyr cutting allows the formation of a negative DNA supercoil which enables replication of DNA. Gyr consists of 2 subunits: GyrA and GyrB. Reverse gyrase (Top-RG) is a type of topoisomerase I which catalyses the formation of positive DNA supercoil.
3D Structure of Gyrase
Gyrase Subunit A
3l6v – GyrA C-terminal – Xanthomonas campestris
2wl2 – EcGyrA N-terminal+simocylinone – Escherichia coli
1ajb - EcGyrA N-terminal+novobiocin
1zi0, 1ab4 - EcGyrA C-terminal
1x75 – EcGyrA14+CcdB
3ilw - MtGyrA N-terminal – Mycobacterium tuberculosis
1suu - GyrA C-terminal – Borrelia burgdorferi
Gyrase Subunit B
[3g75]], 3g7b, 3g7e – GyrB+thiazole inhibitor – Staphylococcus aureus
2cjt - MtGyrB C-terminal
3cwv – GyrB truncated – Myxococcus xanthus
1kzn, 1ei1 - EcGyrB N-terminal+clorobiocin
1kij – GyrB domain+novobiocin – Thermus thermophilus
Reverse Gyrase
1gku – AfTop-RG – Archaeoglobus fulgidus
1gl9 - AfTop-RG+ADPNP
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Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman
