Superoxide Dismutase
From Proteopedia
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[[Image:1sos2.jpg|300px|left]] | [[Image:1sos2.jpg|300px|left]] | ||
| - | <applet load="Combo.pdb" size=" | + | <applet load="Combo.pdb" size="300" color="white" frame="true" spin="on" Scene ="Superoxide_Dismutase/Opening_sod/1" caption="Superoxide Dismutase, [[1sos]]" align="right"/> |
'''3D Structure of Superoxide Dismutase'''<br /> | '''3D Structure of Superoxide Dismutase'''<br /> | ||
| - | + | Superoxide dismutase (SOD) are a group of antioxidant enzymes which catalyze the dismutation of superoxide to oxygen and [http://en.wikipedia.org/wiki/Hydrogen_peroxide hydrogen peroxide]. | |
| - | Superoxide dismutase (SOD) are a group of antioxidant enzymes which catalyze the | + | <br /> |
| - | Cu-Zn-SOD, Cu-SOD, Fe-SOD, Mn-SOD. The | + | <br /> |
| + | |||
| + | |||
| + | ==Types of SOD:== | ||
| + | SOD uses metals as cofactors and are named accordingly: Cu-Zn-SOD, Cu-SOD, Fe-SOD, Mn-SOD. The Cu-Zn-SOD is most commonly found in eukaryotes, including humans, while the Fe-SOD and Mn-SOD and Fe-SOD are found in prokaryotes. The 2D and 3D images above are of a Human Cu-Zn-SOD with <scene name='Superoxide_Dismutase/Opening_sod_cuzn/2'>copper and zinc</scene> metal ions visible. | ||
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| + | [[Image:601px-2SOD ribbon pastel.jpg|300px|left]] | ||
| + | <applet load="1q0e2.pdb" size="300" color="white" frame="true" spin="on" Scene ="Superoxide_Dismutase/Second_opening_sod/1" caption="Bovine Superoxide Dismutase, [[1q0e]]" align="right"/> | ||
| + | ==Structure:== | ||
| + | The structure of SOD was first solved by Irwin Fridovich and JoMcCord in 1973<ref>PMID:5389100 </ref> <ref>PMID:28557736</ref>, with the structure of human-like <scene name='Superoxide_Dismutase/Second_opening_sod_cuzn/1'>Cu-ZN</scene> SOD solved soon after by Richardson et al. <ref>PMID:6316150 </ref> The typical SOD structure is an 8-stranded “Greek Key” beta-barrel with an active site buried between the <scene name='Superoxide_Dismutase/Second_beta_barrel/2'>barrel</scene> and <scene name='Superoxide_Dismutase/Second_opening_sod_loops/1'>two surface loops</scene>. While the typical biological unit for SOD is either dimmer or tetramer, monomer forms exist, such as the bovine SOD at the right. The Image at the left by Dr. Jane Richardson, illustrates the Greek-Key structure and position of the metal cations. | ||
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| + | ==Biochemistry== | ||
| + | [http://en.wikipedia.org/wiki/Superoxide Superoxide] is a highly reactive oxygen species and is a major source of oxidative stress in the body, reacting with cellular targets, often causing oxidative damage. <ref>PMID:7493016</ref> SOD protects the body by safely metabolizing the superoxide into unreactive oxygen and hydrogen peroxide. Experiments conducted with knockout mice unable to produce SOD develop widespread oxidative damage and hepatocarcinogenesis and exhibit a greatly reduced lifespan. <ref> PMID:15531919</ref> In humans, mutations to SOD1, one of 3 types found in the human body, can cause familial [http://en.wikipedia.org/wiki/Als ALS], a motor neuron disease better known as Lou Gherig’s Disease <ref> PMID:10970056</ref>, and has also been linked to Down’s Syndrome<ref>PMID:7999984</ref>. | ||
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[[3hog]] – SOD – tomato <br /> | [[3hog]] – SOD – tomato <br /> | ||
| - | [[1p7g]] – SOD – Pyrobaculum aerophilum <br /> | + | [[1p7g]] – SOD – ''Pyrobaculum aerophilum'' <br /> |
===Cu-Zn-SOD=== | ===Cu-Zn-SOD=== | ||
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[[3l9e]] - smSOD +Zn – silk moth<br /> | [[3l9e]] - smSOD +Zn – silk moth<br /> | ||
[[3l9y]] - smSOD +Zn+Cu<br /> | [[3l9y]] - smSOD +Zn+Cu<br /> | ||
| - | [[2wn0]] – YpSOD+Zn+Cu – Yersinia pseudotuberculosis<br /> | + | [[2wn0]] – YpSOD+Zn+Cu – ''Yersinia pseudotuberculosis''<br /> |
[[2wn1]] - YpSOD+Zn+Cu+N3<br /> | [[2wn1]] - YpSOD+Zn+Cu+N3<br /> | ||
[[2z7u]], [[2z7w]], [[2z7y]], [[2z7z]], [[2aeo]], [[1q0e]], [[1e9p]], [[1e9q]], [[1cb4]], [[1cbj]], [[1sxn]], [[1sxa]], [[1sxb]], [[1sxc]], [[1spd]], [[1sda]], [[3sod]], [[2sod]], [[2zow]], [[3hw7]] – cSOD+Zn+Cu - cow<br /> | [[2z7u]], [[2z7w]], [[2z7y]], [[2z7z]], [[2aeo]], [[1q0e]], [[1e9p]], [[1e9q]], [[1cb4]], [[1cbj]], [[1sxn]], [[1sxa]], [[1sxb]], [[1sxc]], [[1spd]], [[1sda]], [[3sod]], [[2sod]], [[2zow]], [[3hw7]] – cSOD+Zn+Cu - cow<br /> | ||
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[[1sxz]] - cSOD +Zn+Cu+N3<br /> | [[1sxz]] - cSOD +Zn+Cu+N3<br /> | ||
[[1e9o]] – cSOD+Cu<br /> | [[1e9o]] – cSOD+Cu<br /> | ||
| - | [[3f7k]] - ApSOD +Zn+Cu+H2O2 – Alvinella pompejana<br /> | + | [[3f7k]] - ApSOD +Zn+Cu+H2O2 – ''Alvinella pompejana''<br /> |
[[3f7l]] - ApSOD +Zn+Cu<br /> | [[3f7l]] - ApSOD +Zn+Cu<br /> | ||
| - | [[2k4w]] – SeSOD (mutant) +Zn+Cu – Salmonella enterica – NMR<br /> | + | [[2k4w]] – SeSOD (mutant) +Zn+Cu – ''Salmonella enterica'' – NMR<br /> |
| - | [[1eqw]] - SOD +Zn+Cu – Salmonella typhimurium<br /> | + | [[1eqw]] - SOD +Zn+Cu – ''Salmonella typhimurium''<br /> |
| - | [[3ce1]] - SOD +Zn+Cu – Cryptococcus liquefaciens<br /> | + | [[3ce1]] - SOD +Zn+Cu – ''Cryptococcus liquefaciens''<br /> |
| - | [[2q2l]] - SOD +Zn – Potentilla atrosanguinea<br /> | + | [[2q2l]] - SOD +Zn – ''Potentilla atrosanguinea''<br /> |
| - | [[2aqm]] - SOD +Zn+Cu – Brucella abortus<br /> | + | [[2aqm]] - SOD +Zn+Cu – ''Brucella abortus''<br /> |
| - | [[2aps]] - SOD +Zn+Cu – Actinobacillus pleuropneumoniae<br /> | + | [[2aps]] - SOD +Zn+Cu – ''Actinobacillus pleuropneumoniae''<br /> |
| - | [[2aqn]] - NmSOD +Zn+Cu – Neisseria meningitides<br /> | + | [[2aqn]] - NmSOD +Zn+Cu – ''Neisseria meningitides''<br /> |
[[2aqp]], [[2aqq]], [[2aqr]], [[2aqs]], [[2aqt]] – NmSOD (mutant) +Zn+Cu<br /> | [[2aqp]], [[2aqq]], [[2aqr]], [[2aqs]], [[2aqt]] – NmSOD (mutant) +Zn+Cu<br /> | ||
| - | [[1z9n]] - HdSOD +Zn+Cu+haem – Haemophilus ducreyi<br /> | + | [[1z9n]] - HdSOD +Zn+Cu+haem – ''Haemophilus ducreyi''<br /> |
[[1z9p]] - HdSOD +Zn+Cu<br /> | [[1z9p]] - HdSOD +Zn+Cu<br /> | ||
| - | [[1to4]], [[1to5]] - SOD +Zn+Cu – Schistosoma mansoni<br /> | + | [[1to4]], [[1to5]] - SOD +Zn+Cu – ''Schistosoma mansoni''<br /> |
| - | [[1pzs]] - MtSOD +Cu – Mycobacterium tuberculosis<br /> | + | [[1pzs]] - MtSOD +Cu – ''Mycobacterium tuberculosis''<br /> |
| - | [[1oaj]], [[1bzo]], [[1yai]] - PlSOD +Zn+Cu – Photobacterium leiognathi<br /> | + | [[1oaj]], [[1bzo]], [[1yai]] - PlSOD +Zn+Cu – ''Photobacterium leiognathi''<br /> |
[[1oal]], [[1ib5]], [[1ibb]], [[1ibd]], [[1ibf]], [[1ibh]] – PlSOD (mutant) +Zn+Cu<br /> | [[1oal]], [[1ib5]], [[1ibb]], [[1ibd]], [[1ibf]], [[1ibh]] – PlSOD (mutant) +Zn+Cu<br /> | ||
[[1f18]], [[1f1a]], [[1f1d]], [[1b4t]] – ySOD (mutant) +Zn+Cu – yeast<br /> | [[1f18]], [[1f1a]], [[1f1d]], [[1b4t]] – ySOD (mutant) +Zn+Cu – yeast<br /> | ||
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[[1yaz]] - ySOD +Zn+Cu+N3<br /> | [[1yaz]] - ySOD +Zn+Cu+N3<br /> | ||
[[1jk9]] – ySOD+Zn+Cu chaperone for SOD<br /> | [[1jk9]] – ySOD+Zn+Cu chaperone for SOD<br /> | ||
| - | [[1eso]] - EcSOD +Zn+Cu - Escherichia coli<br /> | + | [[1eso]] - EcSOD +Zn+Cu - ''Escherichia coli''<br /> |
[[1yso]] - EcSOD +Zn+Cu<br /> | [[1yso]] - EcSOD +Zn+Cu<br /> | ||
[[1srd]] – SOD+MZn+Cu –Spinach<br /> | [[1srd]] – SOD+MZn+Cu –Spinach<br /> | ||
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[[1mmm]] – EcSOD+Fe<br /> | [[1mmm]] – EcSOD+Fe<br /> | ||
[[1zlz]], [[1ixb]], [[1ix9]], [[1en4]], [[1en5]], [[1en6]], [[1i08]], [[1i0h]] – EcSOD (mutant)+Mn<br /> | [[1zlz]], [[1ixb]], [[1ix9]], [[1en4]], [[1en5]], [[1en6]], [[1i08]], [[1i0h]] – EcSOD (mutant)+Mn<br /> | ||
| - | [[3dc5]], [[3dc6]] – SOD+Mn – Caenorhabditis elegans<br /> | + | [[3dc5]], [[3dc6]] – SOD+Mn – ''Caenorhabditis elegans''<br /> |
[[3bfr]], [[1jcv]] – ySOD+Mn <br /> | [[3bfr]], [[1jcv]] – ySOD+Mn <br /> | ||
[[2qka]], [[2adp]], [[2adq]], [[1xdc]], [[1xil]], [[1n0j]], [[1luv]], [[1msd]] – hSOD+Mn<br /> | [[2qka]], [[2adp]], [[2adq]], [[1xdc]], [[1xil]], [[1n0j]], [[1luv]], [[1msd]] – hSOD+Mn<br /> | ||
[[2qkc]], [[3c3s]], [[3c3t]], [[2p4k]], [[1zsp]], [[1zte]], [[1zuq]], [[2gds]], [[1szx]], [[1pl4]], [[1pm9]], [[1n0n]], [[1luw]], [[1ja8]], [[1em1]], [[1ap5]], [[1ap6]], [[1qnm]], [[1var]] – hSOD (mutant)+Mn<br /> | [[2qkc]], [[3c3s]], [[3c3t]], [[2p4k]], [[1zsp]], [[1zte]], [[1zuq]], [[2gds]], [[1szx]], [[1pl4]], [[1pm9]], [[1n0n]], [[1luw]], [[1ja8]], [[1em1]], [[1ap5]], [[1ap6]], [[1qnm]], [[1var]] – hSOD (mutant)+Mn<br /> | ||
| - | [[2rcv]] – SOD+Mn – Bacillus subtilis<br /> | + | [[2rcv]] – SOD+Mn – ''Bacillus subtilis''<br /> |
| - | [[1xre]], [[1xuq]] – SOD+Mn – Bacillus anthracis<br /> | + | [[1xre]], [[1xuq]] – SOD+Mn – ''Bacillus anthracis''<br /> |
| - | [[2aw9]], [[2cdy]], [[2ce4]] – DrSOD+Mn – Deinococcus radiodurans<br /> | + | [[2aw9]], [[2cdy]], [[2ce4]] – DrSOD+Mn – ''Deinococcus radiodurans''<br /> |
[[1y67]] – DrSOD+Fe<br /> | [[1y67]] – DrSOD+Fe<br /> | ||
| - | [[2a03]] – SOD+Mn+Zn – Plasmodium berghei<br /> | + | [[2a03]] – SOD+Mn+Zn – ''Plasmodium berghei''<br /> |
| - | [[1jr9]] - SOD +Zn+Mn – Virgibacillus halodenitrificans<br /> | + | [[1jr9]] - SOD +Zn+Mn – ''Virgibacillus halodenitrificans''<br /> |
| - | [[1gv3]] – SOD+Mn – Anabaena<br /> | + | [[1gv3]] – SOD+Mn – ''Anabaena''<br /> |
| - | [[1kkc]] – SOD+Mn – Aspergillus fumigatus<br /> | + | [[1kkc]] – SOD+Mn – ''Aspergillus fumigatus''<br /> |
| - | [[1xso]] – SOD+Mn – Xenopus laevis<br /> | + | [[1xso]] – SOD+Mn – ''Xenopus laevis''<br /> |
| - | [[1mng]], [[3mds]] – TtSOD+Mn – Thermus thermophilus<br /> | + | [[1mng]], [[3mds]] – TtSOD+Mn – ''Thermus thermophilus''<br /> |
===Fe-SOD=== | ===Fe-SOD=== | ||
| - | [[3js4]] – SOD+Fe – Anaplasma phagocytuphilum<br /> | + | [[3js4]] – SOD+Fe – ''Anaplasma phagocytuphilum''<br /> |
| - | [[3evk]] – SOD+Mn – Pyrobaculum aerophilum<br /> | + | [[3evk]] – SOD+Mn – ''Pyrobaculum aerophilum''<br /> |
| - | [[3esf]] – SOD (mutant)+Fe – Trypanosoma brucei<br /> | + | [[3esf]] – SOD (mutant)+Fe – ''Trypanosoma brucei''<br /> |
| - | [[2gpc]] – SOD+Fe – Trypanosoma cruzi<br /> | + | [[2gpc]] – SOD+Fe – ''Trypanosoma cruzi''<br /> |
| - | [[3h1s]] – SOD+Fe – Francisella tularensis<br /> | + | [[3h1s]] – SOD+Fe – ''Francisella tularensis''<br /> |
| - | [[2w7w]] – SOD+Fe – Aliivibrio salmonicida<br /> | + | [[2w7w]] – SOD+Fe – ''Aliivibrio salmonicida''<br /> |
| - | [[3cei]] – SOD+Fe – Helicobacter pylori<br /> | + | [[3cei]] – SOD+Fe – ''Helicobacter pylori''<br /> |
| - | [[2goj]], [[2bpi]] – PfSOD+Fe – Plasmodium falciparum<br /> | + | [[2goj]], [[2bpi]] – PfSOD+Fe – ''Plasmodium falciparum''<br /> |
| - | [[2awp]] – SOD+ion – Plasmodium knowlesi<br /> | + | [[2awp]] – SOD+ion – ''Plasmodium knowlesi''<br /> |
[[2bkb]], [[2nyb]], [[1za5]] – EcSOD (mutant)+Fe<br /> | [[2bkb]], [[2nyb]], [[1za5]] – EcSOD (mutant)+Fe<br /> | ||
| - | [[2cw2]], [[2cw3]] – SOD+Fe – Perkinsus marinus<br /> | + | [[2cw2]], [[2cw3]] – SOD+Fe – ''Perkinsus marinus''<br /> |
| - | [[1wb7]], [[1wb8]] – SOD (mutant)+Fe – Sulfolobus solfataricus<br /> | + | [[1wb7]], [[1wb8]] – SOD (mutant)+Fe – ''Sulfolobus solfataricus''<br /> |
| - | [[1unf]] – SOD+Fe – Vigna unguiculata<br /> | + | [[1unf]] – SOD+Fe – ''Vigna unguiculata''<br /> |
| - | [[1uer]], [[1ues]], [[1qnn]] – SOD+Fe – Porphyromonas gingivalis<br /> | + | [[1uer]], [[1ues]], [[1qnn]] – SOD+Fe – ''Porphyromonas gingivalis''<br /> |
| - | [[1my6]] – SOD+Fe – Thermosynechococcus elongates<br /> | + | [[1my6]] – SOD+Fe – ''Thermosynechococcus elongates''<br /> |
| - | [[1ma1]] – SOD+Fe – Methanothermobacter thermautotrophicus<br /> | + | [[1ma1]] – SOD+Fe – ''Methanothermobacter thermautotrophicus''<br /> |
[[1gn2]], [[1gn3]], [[1gn4]], [[1gn6]] – MtSOD (mutant)+Fe<br /> | [[1gn2]], [[1gn3]], [[1gn4]], [[1gn6]] – MtSOD (mutant)+Fe<br /> | ||
[[1ids]] – MtSOD+Fe<br /> | [[1ids]] – MtSOD+Fe<br /> | ||
| - | [[1dt0]], [[3sdp]] – SOD+Fe – Pseudomonas putida<br /> | + | [[1dt0]], [[3sdp]] – SOD+Fe – ''Pseudomonas putida''<br /> |
| - | [[1b06]] – SOD+Fe – Sulfolobus acidocaldarius<br /> | + | [[1b06]] – SOD+Fe – ''Sulfolobus acidocaldarius''<br /> |
| - | [[1bs3]] – PfSOD+Fe+F – Propionibacterium freudenreichii<br /> | + | [[1bs3]] – PfSOD+Fe+F – ''Propionibacterium freudenreichii''<br /> |
[[1bsm]], [[1bt8]] – PfSOD+Fe<br /> | [[1bsm]], [[1bt8]] – PfSOD+Fe<br /> | ||
[[1ar4]], [[1ar5]] – PfSOD+Mn<br /> | [[1ar4]], [[1ar5]] – PfSOD+Mn<br /> | ||
[[1avm]] – PfSOD+Fe+N3<br /> | [[1avm]] – PfSOD+Fe+N3<br /> | ||
| - | [[1coj]] – SOD+Fe – Aquifex pyrophilus<br /> | + | [[1coj]] – SOD+Fe – ''Aquifex pyrophilus''<br /> |
[[1isa]], [[1isb]], [[1isc]] – EcSOD+Fe <br /> | [[1isa]], [[1isb]], [[1isc]] – EcSOD+Fe <br /> | ||
===Ni-SOD=== | ===Ni-SOD=== | ||
| - | [[3g4x]], [[3g4z]], [[3g50]], [[1t6u]] – ScSOD (mutant)+Ni – Streptomyces coelicolor<br /> | + | [[3g4x]], [[3g4z]], [[3g50]], [[1t6u]] – ScSOD (mutant)+Ni – ''Streptomyces coelicolor''<br /> |
[[1t6i]], [[1t6q]] – ScSOD apo <br /> | [[1t6i]], [[1t6q]] – ScSOD apo <br /> | ||
| - | [[1q0d]], [[1q0f]], [[1q0g]], [[1q0k]], [[1q0m]] – SOD+Ni – Streptomyces seoulensis<br /> | + | [[1q0d]], [[1q0f]], [[1q0g]], [[1q0k]], [[1q0m]] – SOD+Ni – ''Streptomyces seoulensis''<br /> |
Revision as of 07:29, 25 July 2010
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3D Structure of Superoxide Dismutase
Superoxide dismutase (SOD) are a group of antioxidant enzymes which catalyze the dismutation of superoxide to oxygen and hydrogen peroxide.
Contents |
Types of SOD:
SOD uses metals as cofactors and are named accordingly: Cu-Zn-SOD, Cu-SOD, Fe-SOD, Mn-SOD. The Cu-Zn-SOD is most commonly found in eukaryotes, including humans, while the Fe-SOD and Mn-SOD and Fe-SOD are found in prokaryotes. The 2D and 3D images above are of a Human Cu-Zn-SOD with metal ions visible.
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Structure:
The structure of SOD was first solved by Irwin Fridovich and JoMcCord in 1973[1] [2], with the structure of human-like SOD solved soon after by Richardson et al. [3] The typical SOD structure is an 8-stranded “Greek Key” beta-barrel with an active site buried between the and . While the typical biological unit for SOD is either dimmer or tetramer, monomer forms exist, such as the bovine SOD at the right. The Image at the left by Dr. Jane Richardson, illustrates the Greek-Key structure and position of the metal cations.
Biochemistry
Superoxide is a highly reactive oxygen species and is a major source of oxidative stress in the body, reacting with cellular targets, often causing oxidative damage. [4] SOD protects the body by safely metabolizing the superoxide into unreactive oxygen and hydrogen peroxide. Experiments conducted with knockout mice unable to produce SOD develop widespread oxidative damage and hepatocarcinogenesis and exhibit a greatly reduced lifespan. [5] In humans, mutations to SOD1, one of 3 types found in the human body, can cause familial ALS, a motor neuron disease better known as Lou Gherig’s Disease [6], and has also been linked to Down’s Syndrome[7].
3D Structures of SOD
Metal-free apo SOD
3hog – SOD – tomato
1p7g – SOD – Pyrobaculum aerophilum
Cu-Zn-SOD
2jlp, 2v0a, 2c9v, 2c9u, 2c9s, 1pu0, 1hl5, 1sos, 1spd - hSOD +Zn+Cu - human
3h2p, 3h2q, 3h2r, 3hff, 3gqf, 2nnx, 1p1v, 1oez – hSOD (mutant) +Zn
2af2, 1kmg - hSOD (mutant) +Zn – NMR
1l3n, 1dsw, 1ba9 – hSOD (mutant) +Zn+Cu - NMR
1rk7 - hSOD (mutant) apo – NMR
1ozt, 3gzp, 3gzq, 3ecv, 3ecw, 2gbu - hSOD (mutant) apo
3ecu, 3k91 – hSOD apo
2r27 - hSOD +Cu
1hl4 - hSOD +Zn
2wko, 3gzo, 2zkw, 2zkx, 2zky, 3cqp, 3cqq, 2vr6, 2vr7, 2vr8, 2gbt, 2gbv, 1uxl, 1uxm, 1ptz, 1ozu, 1n18, 1n19, 1fun, 1mfm, 1azv – hSOD (mutant) +Zn+Cu
3l9e - smSOD +Zn – silk moth
3l9y - smSOD +Zn+Cu
2wn0 – YpSOD+Zn+Cu – Yersinia pseudotuberculosis
2wn1 - YpSOD+Zn+Cu+N3
2z7u, 2z7w, 2z7y, 2z7z, 2aeo, 1q0e, 1e9p, 1e9q, 1cb4, 1cbj, 1sxn, 1sxa, 1sxb, 1sxc, 1spd, 1sda, 3sod, 2sod, 2zow, 3hw7 – cSOD+Zn+Cu - cow
1cob – cSOD+Cu+Co
1sxs - cSOD +Zn+Cu+SCN
1sxz - cSOD +Zn+Cu+N3
1e9o – cSOD+Cu
3f7k - ApSOD +Zn+Cu+H2O2 – Alvinella pompejana
3f7l - ApSOD +Zn+Cu
2k4w – SeSOD (mutant) +Zn+Cu – Salmonella enterica – NMR
1eqw - SOD +Zn+Cu – Salmonella typhimurium
3ce1 - SOD +Zn+Cu – Cryptococcus liquefaciens
2q2l - SOD +Zn – Potentilla atrosanguinea
2aqm - SOD +Zn+Cu – Brucella abortus
2aps - SOD +Zn+Cu – Actinobacillus pleuropneumoniae
2aqn - NmSOD +Zn+Cu – Neisseria meningitides
2aqp, 2aqq, 2aqr, 2aqs, 2aqt – NmSOD (mutant) +Zn+Cu
1z9n - HdSOD +Zn+Cu+haem – Haemophilus ducreyi
1z9p - HdSOD +Zn+Cu
1to4, 1to5 - SOD +Zn+Cu – Schistosoma mansoni
1pzs - MtSOD +Cu – Mycobacterium tuberculosis
1oaj, 1bzo, 1yai - PlSOD +Zn+Cu – Photobacterium leiognathi
1oal, 1ib5, 1ibb, 1ibd, 1ibf, 1ibh – PlSOD (mutant) +Zn+Cu
1f18, 1f1a, 1f1d, 1b4t – ySOD (mutant) +Zn+Cu – yeast
1f1g, 1b4l, 2jcw, 1sdy - ySOD +Zn+Cu
1yaz - ySOD +Zn+Cu+N3
1jk9 – ySOD+Zn+Cu chaperone for SOD
1eso - EcSOD +Zn+Cu - Escherichia coli
1yso - EcSOD +Zn+Cu
1srd – SOD+MZn+Cu –Spinach
Mn-SOD
3k9s – EcSOD+H2O2
1d5n, 1vew - EcSOD+Mn
1mmm – EcSOD+Fe
1zlz, 1ixb, 1ix9, 1en4, 1en5, 1en6, 1i08, 1i0h – EcSOD (mutant)+Mn
3dc5, 3dc6 – SOD+Mn – Caenorhabditis elegans
3bfr, 1jcv – ySOD+Mn
2qka, 2adp, 2adq, 1xdc, 1xil, 1n0j, 1luv, 1msd – hSOD+Mn
2qkc, 3c3s, 3c3t, 2p4k, 1zsp, 1zte, 1zuq, 2gds, 1szx, 1pl4, 1pm9, 1n0n, 1luw, 1ja8, 1em1, 1ap5, 1ap6, 1qnm, 1var – hSOD (mutant)+Mn
2rcv – SOD+Mn – Bacillus subtilis
1xre, 1xuq – SOD+Mn – Bacillus anthracis
2aw9, 2cdy, 2ce4 – DrSOD+Mn – Deinococcus radiodurans
1y67 – DrSOD+Fe
2a03 – SOD+Mn+Zn – Plasmodium berghei
1jr9 - SOD +Zn+Mn – Virgibacillus halodenitrificans
1gv3 – SOD+Mn – Anabaena
1kkc – SOD+Mn – Aspergillus fumigatus
1xso – SOD+Mn – Xenopus laevis
1mng, 3mds – TtSOD+Mn – Thermus thermophilus
Fe-SOD
3js4 – SOD+Fe – Anaplasma phagocytuphilum
3evk – SOD+Mn – Pyrobaculum aerophilum
3esf – SOD (mutant)+Fe – Trypanosoma brucei
2gpc – SOD+Fe – Trypanosoma cruzi
3h1s – SOD+Fe – Francisella tularensis
2w7w – SOD+Fe – Aliivibrio salmonicida
3cei – SOD+Fe – Helicobacter pylori
2goj, 2bpi – PfSOD+Fe – Plasmodium falciparum
2awp – SOD+ion – Plasmodium knowlesi
2bkb, 2nyb, 1za5 – EcSOD (mutant)+Fe
2cw2, 2cw3 – SOD+Fe – Perkinsus marinus
1wb7, 1wb8 – SOD (mutant)+Fe – Sulfolobus solfataricus
1unf – SOD+Fe – Vigna unguiculata
1uer, 1ues, 1qnn – SOD+Fe – Porphyromonas gingivalis
1my6 – SOD+Fe – Thermosynechococcus elongates
1ma1 – SOD+Fe – Methanothermobacter thermautotrophicus
1gn2, 1gn3, 1gn4, 1gn6 – MtSOD (mutant)+Fe
1ids – MtSOD+Fe
1dt0, 3sdp – SOD+Fe – Pseudomonas putida
1b06 – SOD+Fe – Sulfolobus acidocaldarius
1bs3 – PfSOD+Fe+F – Propionibacterium freudenreichii
1bsm, 1bt8 – PfSOD+Fe
1ar4, 1ar5 – PfSOD+Mn
1avm – PfSOD+Fe+N3
1coj – SOD+Fe – Aquifex pyrophilus
1isa, 1isb, 1isc – EcSOD+Fe
Ni-SOD
3g4x, 3g4z, 3g50, 1t6u – ScSOD (mutant)+Ni – Streptomyces coelicolor
1t6i, 1t6q – ScSOD apo
1q0d, 1q0f, 1q0g, 1q0k, 1q0m – SOD+Ni – Streptomyces seoulensis
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