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Tropomyosin
From Proteopedia
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[[Image:1c1g.png|left|300px]] | [[Image:1c1g.png|left|300px]] | ||
| - | {{STRUCTURE_1c1g| PDB=1c1g | SIZE=400| SCENE=Tropomyosin/Cv/1 |CAPTION=Tropomyosin from | + | {{STRUCTURE_1c1g| PDB=1c1g | SIZE=400| SCENE=Tropomyosin/Cv/1 |CAPTION=Tropomyosin from pig, [[1c1g]] }} |
'''3D Structure of Tropomyosin''' <br /> | '''3D Structure of Tropomyosin''' <br /> | ||
| - | The image at the left is a Tropomyosin from | + | The image at the left is a Tropomyosin from pig ([[1c1g]]). |
{{Clear}} | {{Clear}} | ||
== Tropomyosin == | == Tropomyosin == | ||
| - | Tropomyosin (TPM) has a 4-helix coiled dimer structure. It regulates the binding of myosin thus regulating muscle contraction. In its locked conformation it binds troponin T (TnnT) and prevents the binding of myosin to actin. When Ca+ | + | Tropomyosin (TPM) has a 4-helix coiled dimer structure. It regulates the binding of myosin thus regulating muscle contraction. In its locked conformation it binds troponin T (TnnT) and prevents the binding of myosin to actin. When Ca++ ions bind to TnnT, the TPM assumes an open conformation and myosin can bind to actin. You can <scene name='Tropomyosin/Cv/2'>enlarge the image</scene> at the right for clarity. |
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[[1ic2]] - cTPM alpha-1 (mutant)<br /> | [[1ic2]] - cTPM alpha-1 (mutant)<br /> | ||
[[2w49]] – cTnnC+cTnnT+cTnnI+cTPM alpha-1+cActin<br /> | [[2w49]] – cTnnC+cTnnT+cTnnI+cTPM alpha-1+cActin<br /> | ||
| - | [[2z5h]] – yTPM alpha-1 N-terminal+C-terminal+GNC4+TnnT – yeast<br /> | + | [[2z5h]] – yTPM alpha-1 N-terminal+C-terminal+GNC4 leucine zipper+TnnT – yeast<br /> |
| - | [[2z5i]] - yTPM alpha-1 N-terminal+C-terminal+GNC4<br /> | + | [[2z5i]] - yTPM alpha-1 N-terminal+C-terminal+GNC4 leucine zipper<br /> |
| - | [[2efr]], [[2efs]], [[2d3e]] - rTPM alpha-1 C-terminal+GNC4 – rabbit<br /> | + | [[2efr]], [[2efs]], [[2d3e]] - rTPM alpha-1 C-terminal+GNC4 leucine zipper – rabbit<br /> |
| - | [[1kql]] - TPM alpha-1 C-terminal+GNC4 - rat<br /> | + | [[1kql]] - TPM alpha-1 C-terminal+GNC4 leucine zipper - rat<br /> |
[[2b9c]] – TPM mid region – rat<br /> | [[2b9c]] – TPM mid region – rat<br /> | ||
[[1c1g]] – TPM – pig<br /> | [[1c1g]] – TPM – pig<br /> | ||
[[2tma]] – TPM - model<br /> | [[2tma]] – TPM - model<br /> | ||
Revision as of 07:45, 25 July 2010
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| Tropomyosin from pig, 1c1g | |||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
3D Structure of Tropomyosin
The image at the left is a Tropomyosin from pig (1c1g).
Tropomyosin
Tropomyosin (TPM) has a 4-helix coiled dimer structure. It regulates the binding of myosin thus regulating muscle contraction. In its locked conformation it binds troponin T (TnnT) and prevents the binding of myosin to actin. When Ca++ ions bind to TnnT, the TPM assumes an open conformation and myosin can bind to actin. You can at the right for clarity.
3D Structures of Tropomyosin
3mtu, 3mud – cTPM alpha-1 – chicken
1ic2 - cTPM alpha-1 (mutant)
2w49 – cTnnC+cTnnT+cTnnI+cTPM alpha-1+cActin
2z5h – yTPM alpha-1 N-terminal+C-terminal+GNC4 leucine zipper+TnnT – yeast
2z5i - yTPM alpha-1 N-terminal+C-terminal+GNC4 leucine zipper
2efr, 2efs, 2d3e - rTPM alpha-1 C-terminal+GNC4 leucine zipper – rabbit
1kql - TPM alpha-1 C-terminal+GNC4 leucine zipper - rat
2b9c – TPM mid region – rat
1c1g – TPM – pig
2tma – TPM - model
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Gregory Hoeprich, Jaime Prilusky, David Canner, Joel L. Sussman
