Ferritin
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2jd73.png|thumb|left| | + | [[Image:2jd73.png|thumb|left|250px|Crystal structure of ferritin from ''Pyrococcs Furiousus'' ([[2jd7]])]] |
<applet load='Pdb2jd7.pdb' size='350' frame='true' align='right' scene="Ferritin/Starting_ferritin_scene/1" caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'', [[2jd7]]" /> | <applet load='Pdb2jd7.pdb' size='350' frame='true' align='right' scene="Ferritin/Starting_ferritin_scene/1" caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'', [[2jd7]]" /> | ||
Revision as of 15:14, 25 July 2010
|
Ferritin (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL). Bacterioferritin (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity. Thioferritin (TFR) is a ferritin-related protein with 2 Cysteine residues adjacent to the dimetal binding site. Another iron storing protein is the DNA-binding Protein of Starved cells (Dps). MrgA – another iron storage protein - belongs to the Dps family.
Contents |
3D Structures of Ferritin
Ferritin
2jd6, 2jd7 – PfFR - Pyrococcus furiosus
2jd8 – PfFR+Zn
3kxu – hFR (mutant) – human
3hx2, 3hx5, 3hx7 - hFR
3a68 – soFR from gene SferH4 – soybean
3a9q - soFR from gene SferH4 (mutant)
3egm, 3bvf, 3bvi, 3bvk, 3bvl – HpFR – Heliobacter pylori
3e6s - PnFR – Pseudo-nitzschia
1z4a, 1vlg – FR – Thermotoga maritime
1s3q, 1sq3 – FR – Archaeoglubus fulgidus
1krq – FR – Campylobacter jejuni
1eum - EcFR – Escherichia coli
1qgh – LiFR - Listeria innocua
1mfr, 1bg7 – bFR - Bullfrog
Ferritin light chain (FTL)
1lb3, 1h96 – FTL – mouse
1rcc, 1rcd, 1rci – bFTL+tartrate+Mg
1rce, 1rcg - bFTL+tartrate+Mn
Ferritin heavy chain (FTH)
2z6m, 1r03, 2fha – hFTH
2z6o – FTH – Trichoplusia ni
apo-ferritin (apo-FR)
2x17 – apo-PfFR+Ag
3h7g – apo-hoFR+Au – horse
1hrs - apo-hoFR+protoporphyrin
3bve – apo-HpFR
3e6r – apo-PnFR
2clu, 2cn6 - apo-hFR (mutant)+Zn
apo-ferritin light chain (apo-FTL)
2zg7, 2z5p, 2z5q, 2z5r, 3fi6 – apo-hoFTL+Pd
2zg8, 2zg9 - apo-hoFTL (mutant)+Pd
3f33, 3f34, 3f35, 3f36, 3f37, 3f38, 3f39 - apo-hoFTL+phenols
2v2i, 2v2j - apo-hoFTL+haemin
2gyd - apo-hoFTL+diaziflurane
1xz1 - apo-hoFTL+halothane
1xz3 - apo-hoFTL+isoflurane
1gwg - apo-hoFTL+I3
2w0o – apo-hoFTL
2v2l, 2v2m, 2v2n, 2v2o, 2v2p, 2v2r, 2v2s - apo-hoFTL (mutant)+haemin
2za6, 2g4h, 1aew, 1dat, 1ier, 1ies, 3f32, 2zur - apo-hoFTL
2ffx, 2fg4, 2fg8 – apo-hFTL
apo-ferritin heavy chain (apo-FTH)
2za7, 2za8, 2cn7, 2chi, 2clu - apo-hoFTH (mutant)
2cei, 2cih, 2cn6, 2iu2 - apo-hoFTH (mutant)+Zn
3erz – apo-hFR+Hg
3es3 - apo-hFR+Au
Bacterioferritin (BFR)
3gvy – BFR – Rhodobacter sphaeroides
3fvb – BmBFR - Brucelia melitensis
2fkz, 2fl0 – BFR – Azotobacrter vinelandii
1bfr – EcBFR
Thioferritin (TFR)
2vzb – TFR – Bacterioides fragilis
DNA-binding Protein of Starved cells (Dps)
3iq1 – Dps – Vibrio cholerae
3ge4 – BmDps
2iy4 – Dps – Listeria monocytogenes
2bkc, 2bk6, 2bjy – LiDps (mutant)
2f7n – Dps – Deinococcus radiodurans
1tjo, 1tk6, 1tkp, 1moj – Dps – Halobacterium salinarum
1o9r – Dps – Agrobacterium tumefaciens
1dps – EcDps
MrgA
2chp – MrgA – Bacillus subtilis
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Joel L. Sussman, David Canner, Eran Hodis, Alexander Berchansky
