Fibrinogen
From Proteopedia
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<applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Fibrinogen_starting_scene/2" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' /> | <applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Fibrinogen_starting_scene/2" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' /> | ||
| - | + | '''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing Knobs A & B to form fibrin. It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained. | |
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{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
| - | ==Fibrinogen== | + | ==3D Structure of Fibrinogen== |
| - | Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (Fba, Fbb, Fbg) . | + | Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (Fba, Fbb, Fbg) . |
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===Fibrinogen alpha+beta+gamma chains=== | ===Fibrinogen alpha+beta+gamma chains=== | ||
Revision as of 05:40, 26 July 2010
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Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing Knobs A & B to form fibrin. It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained.
Contents |
3D Structure of Fibrinogen
Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (Fba, Fbb, Fbg) .
Fibrinogen alpha+beta+gamma chains
3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
1jy3, 1deq – cFba+cFbb+cFbg - cow
1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
1m1j - heFba+heFbb+heFbg+peptide ligand – hen
1ei3 - heFba+heFbb+heFbg
Fibrinogen alpha chain
1fzd – hFba EC domain
2jor – cFba – NMR
2baf – cFba
Fibrinogen beta chain
1fzf, 1fzg – hFb fragment double-D +peptide ligand
1fze, 1fza, 1fzb – hFb fragment D
Fibrinogen gamma chain
2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains
2fib, 3fib - hFbg+peptide ligand
1fib – hFbg+Ca
1fic, 1fid - hFbg
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, David Canner, Mark Hoelzer, Alexander Berchansky, Angel Herraez
