Fibrinogen
From Proteopedia
| Line 3: | Line 3: | ||
<applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Fibrinogen_starting_scene/2" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' /> | <applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Fibrinogen_starting_scene/2" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' /> | ||
| - | '''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing Knobs A & B to form fibrin. It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained. | + | '''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing Knobs A & B to form fibrin. <ref>PMID:692730</ref> It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained. <ref>PMID:18673233</ref> |
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
| Line 40: | Line 40: | ||
[[1fib]] – hFbg+Ca<br /> | [[1fib]] – hFbg+Ca<br /> | ||
[[1fic]], [[1fid]] - hFbg<br /> | [[1fic]], [[1fid]] - hFbg<br /> | ||
| + | |||
| + | ==References== | ||
| + | <references /> | ||
Revision as of 05:42, 26 July 2010
|
Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing Knobs A & B to form fibrin. [1] It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained. [2]
Contents |
3D Structure of Fibrinogen
Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (Fba, Fbb, Fbg) .
Fibrinogen alpha+beta+gamma chains
3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
1jy3, 1deq – cFba+cFbb+cFbg - cow
1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
1m1j - heFba+heFbb+heFbg+peptide ligand – hen
1ei3 - heFba+heFbb+heFbg
Fibrinogen alpha chain
1fzd – hFba EC domain
2jor – cFba – NMR
2baf – cFba
Fibrinogen beta chain
1fzf, 1fzg – hFb fragment double-D +peptide ligand
1fze, 1fza, 1fzb – hFb fragment D
Fibrinogen gamma chain
2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains
2fib, 3fib - hFbg+peptide ligand
1fib – hFbg+Ca
1fic, 1fid - hFbg
References
- ↑ Blomback B, Hessel B, Hogg D, Therkildsen L. A two-step fibrinogen--fibrin transition in blood coagulation. Nature. 1978 Oct 12;275(5680):501-5. PMID:692730
- ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, David Canner, Mark Hoelzer, Alexander Berchansky, Angel Herraez
