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Gyrase
From Proteopedia
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===Gyrase Subunit A=== | ===Gyrase Subunit A=== | ||
| - | [[3l6v]] – GyrA C-terminal – Xanthomonas campestris <br /> | + | [[3l6v]] – GyrA C-terminal – ''Xanthomonas campestris'' <br /> |
| - | [[2wl2]] – EcGyrA N-terminal+simocylinone – Escherichia coli<br /> | + | [[2wl2]] – EcGyrA N-terminal+simocylinone – ''Escherichia coli''<br /> |
[[1ajb]] - EcGyrA N-terminal+novobiocin<br /> | [[1ajb]] - EcGyrA N-terminal+novobiocin<br /> | ||
[[1zi0]], [[1ab4]] - EcGyrA C-terminal<br /> | [[1zi0]], [[1ab4]] - EcGyrA C-terminal<br /> | ||
[[1x75]] – EcGyrA14+CcdB<br /> | [[1x75]] – EcGyrA14+CcdB<br /> | ||
| - | [[3ilw]] - MtGyrA N-terminal – Mycobacterium tuberculosis<br /> | + | [[3ilw]] - MtGyrA N-terminal – ''Mycobacterium tuberculosis''<br /> |
| - | [[1suu]] - GyrA C-terminal – Borrelia burgdorferi<br /> | + | [[1suu]] - GyrA C-terminal – ''Borrelia burgdorferi''<br /> |
===Gyrase Subunit B=== | ===Gyrase Subunit B=== | ||
Revision as of 06:15, 26 July 2010
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Gyrase (Gyr) is a type of topoisomerase II in prokaryotes which unwinds double stranded DNA. The DNA Gyr cutting allows the formation of a negative DNA supercoil which enables replication of DNA. Gyr consists of 2 subunits: GyrA and GyrB. Reverse gyrase (Top-RG) is a type of topoisomerase I which catalyses the formation of positive DNA supercoil.
3D Structure of Gyrase
Gyrase Subunit A
3l6v – GyrA C-terminal – Xanthomonas campestris
2wl2 – EcGyrA N-terminal+simocylinone – Escherichia coli
1ajb - EcGyrA N-terminal+novobiocin
1zi0, 1ab4 - EcGyrA C-terminal
1x75 – EcGyrA14+CcdB
3ilw - MtGyrA N-terminal – Mycobacterium tuberculosis
1suu - GyrA C-terminal – Borrelia burgdorferi
Gyrase Subunit B
3g75, 3g7b, 3g7e – GyrB+thiazole inhibitor – Staphylococcus aureus
2cjt - MtGyrB C-terminal
3cwv – GyrB truncated – Myxococcus xanthus
1kzn, 1ei1 - EcGyrB N-terminal+clorobiocin
1kij – GyrB domain+novobiocin – Thermus thermophilus
Reverse Gyrase
1gku – AfTop-RG – Archaeoglobus fulgidus
1gl9 - AfTop-RG+ADPNP
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman
