2cc3

From Proteopedia

Revision as of 08:45, 30 October 2007

STRUCTURE OF AGROBACTERIUM TUMEFACIENS VIRB8 PROTEIN

Overview

Bacterial type IV secretion systems (T4SS) translocate DNA and/or proteins, to recipient cells, thus providing a mechanism for conjugative transfer of, genetic material and bacterial pathogenesis. Here we describe the first, structure of a core component from the archetypal Agrobacterium, tumefaciens T4SS: the 2.2-A resolution crystal structure of the VirB8, periplasmic domain (pVirB8(AT)). VirB8 forms a dimer in the crystal, and, we identify residues likely important for stabilization of the dimer, interface. Structural comparison of pVirB8(AT) with Brucella suis VirB8, confirms that the monomers have a similar fold. In addition, the, pVirB8(AT) dimer superimposes very closely on the B. suis VirB8 dimer, supporting the proposal that dimer formation in the crystal reflects, ... [(full description)]

About this Structure

2CC3 is a [Single protein] structure of sequence from [Agrobacterium tumefaciens] with MPD as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Agrobacterium tumefaciens VirB8 structure reveals potential protein-protein interaction sites., Bailey S, Ward D, Middleton R, Grossmann JG, Zambryski PC, Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2582-7. Epub 2006 Feb 15. PMID:16481621

Page seeded by OCA on Tue Oct 30 10:50:39 2007