2j1r
From Proteopedia
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| - | [[Image:2j1r. | + | [[Image:2j1r.jpg|left|200px]]<br /><applet load="2j1r" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2j1r" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2j1r, resolution 1.54Å" /> | caption="2j1r, resolution 1.54Å" /> | ||
'''STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE'''<br /> | '''STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2J1R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 2J1R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Ca Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J1R OCA]. |
==Reference== | ==Reference== | ||
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[[Category: sugar binding protein]] | [[Category: sugar binding protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:44:53 2007'' |
Revision as of 17:35, 18 December 2007
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STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE
Overview
The Streptococcus pneumoniae fucose utilization operon includes a gene, encoding a virulence factor that belongs to family 98 in the glycoside, hydrolase classification. This protein contains a C-terminal triplet of, fucose binding modules that have significant amino acid sequence identity, with the Anguilla anguilla fucolectin. Functional studies of these fucose, binding modules reveal binding to fucosylated oligosaccharides and suggest, the importance of multivalent binding. The high resolution crystal, structures of ligand bound forms of one fucose binding module uncovers the, molecular basis of fucose, ABH blood group antigen, and Lewisy antigen, binding. These studies are extended by fluorescence microscopy to show, specific binding to mouse lung tissue. These modules define a new family, of carbohydrate binding modules now classified as family 47.
About this Structure
2J1R is a Single protein structure of sequence from Streptococcus pneumoniae with CA as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Blood group antigen recognition by a Streptococcus pneumoniae virulence factor., Boraston AB, Wang D, Burke RD, J Biol Chem. 2006 Nov 17;281(46):35263-71. Epub 2006 Sep 20. PMID:16987809
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