This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2j3s
From Proteopedia
(New page: 200px<br /> <applet load="2j3s" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j3s, resolution 2.50Å" /> '''CRYSTAL STRUCTURE O...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2j3s.gif|left|200px]]<br /> | + | [[Image:2j3s.gif|left|200px]]<br /><applet load="2j3s" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2j3s" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2j3s, resolution 2.50Å" /> | caption="2j3s, resolution 2.50Å" /> | ||
'''CRYSTAL STRUCTURE OF THE HUMAN FILAMIN A IG DOMAINS 19 TO 21'''<br /> | '''CRYSTAL STRUCTURE OF THE HUMAN FILAMIN A IG DOMAINS 19 TO 21'''<br /> | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2J3S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with BR, DIO and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 2J3S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with BR, DIO and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Dio Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J3S OCA]. |
==Reference== | ==Reference== | ||
| Line 31: | Line 30: | ||
[[Category: structural protein]] | [[Category: structural protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:47:21 2007'' |
Revision as of 17:37, 18 December 2007
|
CRYSTAL STRUCTURE OF THE HUMAN FILAMIN A IG DOMAINS 19 TO 21
Contents |
Overview
Human filamins are large actin-crosslinking proteins composed of an, N-terminal actin-binding domain followed by 24 Ig-like domains (IgFLNs), which interact with numerous transmembrane receptors and cytosolic, signaling proteins. Here we report the 2.5 A resolution structure of a, three-domain fragment of human filamin A (IgFLNa19-21). The structure, reveals an unexpected domain arrangement, with IgFLNa20 partially unfolded, bringing IgFLNa21 into close proximity to IgFLNa19. Notably the N-terminus, of IgFLNa20 forms a beta-strand that associates with the CD face of, IgFLNa21 and occupies the binding site for integrin adhesion receptors., Disruption of this IgFLNa20-IgFLNa21 interaction enhances filamin binding, to integrin beta-tails. Structural and functional analysis of other IgFLN, domains suggests that auto-inhibition by adjacent IgFLN domains may be a, general mechanism controlling filamin-ligand interactions. This can, explain the increased integrin binding of filamin splice variants and, provides a mechanism by which ligand binding might impact filamin, structure.
Disease
Known diseases associated with this structure: Frontometaphyseal dysplasia OMIM:[300017], Heterotopia, periventricular OMIM:[300017], Heterotopia, periventricular nodular, with frontometaphyseal dysplasia OMIM:[300017], Heterotopia, periventricular, ED variant OMIM:[300017], Melnick-Needles syndrome OMIM:[300017], Otopalatodigital syndrome, type I OMIM:[300017], Otopalatodigital syndrome, type II OMIM:[300017]
About this Structure
2J3S is a Single protein structure of sequence from Homo sapiens with BR, DIO and GOL as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding., Lad Y, Kiema T, Jiang P, Pentikainen OT, Coles CH, Campbell ID, Calderwood DA, Ylanne J, EMBO J. 2007 Sep 5;26(17):3993-4004. Epub 2007 Aug 9. PMID:17690686
Page seeded by OCA on Tue Dec 18 19:47:21 2007
