1e5q
From Proteopedia
(New page: 200px<br /> <applet load="1e5q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e5q, resolution 2.10Å" /> '''TERNARY COMPLEX OF ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1E5Q is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Magnaporthe_grisea Magnaporthe grisea]] with NDP and SHR as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.10 1.5.1.10]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E5Q OCA]]. | + | 1E5Q is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Magnaporthe_grisea Magnaporthe grisea]] with NDP and SHR as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Saccharopine_dehydrogenase_(NADP(+),_L-glutamate-forming) Saccharopine dehydrogenase (NADP(+), L-glutamate-forming)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.10 1.5.1.10]]. Structure known Active Sites: NPA, NPB, NPC, NPD, NPE, NPF, NPG, NPH, SCA, SCB, SCC, SCD, SCE, SCF, SCG and SCH. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E5Q OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of saccharopine reductase from Magnaporthe grisea, an enzyme of the alpha-aminoadipate pathway of lysine biosynthesis., Johansson E, Steffens JJ, Lindqvist Y, Schneider G, Structure. 2000 Oct 15;8(10):1037-47. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11080625 11080625] | Crystal structure of saccharopine reductase from Magnaporthe grisea, an enzyme of the alpha-aminoadipate pathway of lysine biosynthesis., Johansson E, Steffens JJ, Lindqvist Y, Schneider G, Structure. 2000 Oct 15;8(10):1037-47. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11080625 11080625] | ||
[[Category: Magnaporthe grisea]] | [[Category: Magnaporthe grisea]] | ||
| + | [[Category: Saccharopine dehydrogenase (NADP(+), L-glutamate-forming)]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Johansson, E.]] | [[Category: Johansson, E.]] | ||
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[[Category: saccharopine reductase]] | [[Category: saccharopine reductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:51:40 2007'' |
Revision as of 08:46, 30 October 2007
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TERNARY COMPLEX OF SACCHAROPINE REDUCTASE FROM MAGNAPORTHE GRISEA, NADPH AND SACCHAROPINE
Overview
BACKGROUND: The biosynthesis of the essential amino acid lysine in higher, fungi and cyanobacteria occurs via the alpha-aminoadipate pathway, which, is completely different from the lysine biosynthetic pathway found in, plants and bacteria. The penultimate reaction in the alpha-aminoadipate, pathway is catalysed by NADPH-dependent saccharopine reductase. We set out, to determine the structure of this enzyme as a first step in exploring the, structural biology of fungal lysine biosynthesis. RESULTS: We have, determined the three-dimensional structure of saccharopine reductase from, the plant pathogen Magnaporthe grisea in its apo form to 2.0 A resolution, and as a ternary complex with NADPH and saccharopine to 2.1 A resolution., Saccharopine reductase is a homodimer, and each subunit ... [(full description)]
About this Structure
1E5Q is a [Single protein] structure of sequence from [Magnaporthe grisea] with NDP and SHR as [ligands]. Active as [Saccharopine dehydrogenase (NADP(+), L-glutamate-forming)], with EC number [1.5.1.10]. Structure known Active Sites: NPA, NPB, NPC, NPD, NPE, NPF, NPG, NPH, SCA, SCB, SCC, SCD, SCE, SCF, SCG and SCH. Full crystallographic information is available from [OCA].
Reference
Crystal structure of saccharopine reductase from Magnaporthe grisea, an enzyme of the alpha-aminoadipate pathway of lysine biosynthesis., Johansson E, Steffens JJ, Lindqvist Y, Schneider G, Structure. 2000 Oct 15;8(10):1037-47. PMID:11080625
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