2j6j
From Proteopedia
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| - | [[Image:2j6j. | + | [[Image:2j6j.jpg|left|200px]]<br /><applet load="2j6j" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2j6j" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2j6j, resolution 3.000Å" /> | caption="2j6j, resolution 3.000Å" /> | ||
'''PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN'''<br /> | '''PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2J6J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus] with NAG and YB as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 2J6J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus] with NAG and YB as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Yb Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J6J OCA]. |
==Reference== | ==Reference== | ||
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[[Category: virion protein]] | [[Category: virion protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:51:11 2007'' |
Revision as of 17:41, 18 December 2007
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PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN
Overview
Glycoprotein G of the vesicular stomatitis virus triggers membrane fusion, via a low pH-induced structural rearrangement. Despite the equilibrium, between the pre- and postfusion states, the structure of the prefusion, form, determined to 3.0 angstrom resolution, shows that the fusogenic, transition entails an extensive structural reorganization of G. Comparison, with the structure of the postfusion form suggests a pathway for the, conformational change. In the prefusion form, G has the shape of a tripod, with the fusion loops exposed, which point toward the viral membrane, and, with the antigenic sites located at the distal end of the molecule. A, large number of G glycoproteins, perhaps organized as in the crystals, act, cooperatively to induce membrane merging.
About this Structure
2J6J is a Single protein structure of sequence from Vesicular stomatitis indiana virus with NAG and YB as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G., Roche S, Rey FA, Gaudin Y, Bressanelli S, Science. 2007 Feb 9;315(5813):843-8. PMID:17289996
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