1o6s
From Proteopedia
(New page: 200px<br /> <applet load="1o6s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1o6s, resolution 1.80Å" /> '''INTERNALIN (LISTERI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1O6S is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] and [[http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]] with CA and CL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O6S OCA]]. | + | 1O6S is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] and [[http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]] with CA and CL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O6S OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: leucine rich repeat]] | [[Category: leucine rich repeat]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:52:21 2007'' |
Revision as of 08:47, 30 October 2007
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INTERNALIN (LISTERIA MONOCYTOGENES) / E-CADHERIN (HUMAN) RECOGNITION COMPLEX
Overview
Listeria monocytogenes, a food-borne bacterial pathogen, enters mammalian, cells by inducing its own phagocytosis. The listerial protein internalin, (InlA) mediates bacterial adhesion and invasion of epithelial cells in the, human intestine through specific interaction with its host cell receptor, E-cadherin. We present the crystal structures of the functional domain of, InlA alone and in a complex with the extracellular, N-terminal domain of, human E-cadherin (hEC1). The leucine rich repeat (LRR) domain of InlA, surrounds and specifically recognizes hEC1. Individual interactions were, probed by mutagenesis and analytical ultracentrifugation. These include, Pro16 of hEC1, a major determinant for human susceptibility to L., monocytogenes infection that is essential for intermolecular ... [(full description)]
About this Structure
1O6S is a [Protein complex] structure of sequences from [Homo sapiens] and [Listeria monocytogenes] with CA and CL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin., Schubert WD, Urbanke C, Ziehm T, Beier V, Machner MP, Domann E, Wehland J, Chakraborty T, Heinz DW, Cell. 2002 Dec 13;111(6):825-36. PMID:12526809
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