2vj6

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==About this Structure==
==About this Structure==
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2VJ6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ6 OCA].
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2VJ6 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ6 OCA].
==Reference==
==Reference==
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[[Category: Ward, J.]]
[[Category: Ward, J.]]
[[Category: Wayne, G.]]
[[Category: Wayne, G.]]
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[[Category: Alternative splicing]]
 
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[[Category: Asp-2]]
 
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[[Category: Aspartyl protease]]
 
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[[Category: Bace-1]]
 
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[[Category: Beta-secretase]]
 
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[[Category: Beta-site app cleaving enzyme]]
 
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Memapsin-2]]
[[Category: Memapsin-2]]
[[Category: Membrane]]
[[Category: Membrane]]
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[[Category: Protease]]
 
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[[Category: Transmembrane]]
 
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[[Category: Zymogen]]
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:56:34 2009''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:03:43 2010''

Revision as of 19:56, 11 August 2010

Template:STRUCTURE 2vj6

HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO-1-PYRROLIDINYL)BENZAMIDE

Template:ABSTRACT PUBMED 18166458

About this Structure

2VJ6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Clarke B, Demont E, Dingwall C, Dunsdon R, Faller A, Hawkins J, Hussain I, MacPherson D, Maile G, Matico R, Milner P, Mosley J, Naylor A, O'Brien A, Redshaw S, Riddell D, Rowland P, Soleil V, Smith KJ, Stanway S, Stemp G, Sweitzer S, Theobald P, Vesey D, Walter DS, Ward J, Wayne G. BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1017-21. Epub 2007 Dec 15. PMID:18166458 doi:10.1016/j.bmcl.2007.12.019

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