2jby
From Proteopedia
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| - | [[Image:2jby.gif|left|200px]]<br /> | + | [[Image:2jby.gif|left|200px]]<br /><applet load="2jby" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2jby" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2jby, resolution 2.41Å" /> | caption="2jby, resolution 2.41Å" /> | ||
'''A VIRAL PROTEIN UNEXPECTEDLY MIMICS THE STRUCTURE AND FUNCTION OF PRO-SURVIVAL BCL-2'''<br /> | '''A VIRAL PROTEIN UNEXPECTEDLY MIMICS THE STRUCTURE AND FUNCTION OF PRO-SURVIVAL BCL-2'''<br /> | ||
| + | |||
| + | ==Overview== | ||
| + | Many viruses express antiapoptotic proteins to counter host defense, mechanisms that would otherwise trigger the rapid clearance of infected, cells. For example, adenoviruses and some gamma-herpesviruses express, homologs of prosurvival Bcl-2 to subvert the host's apoptotic machinery., Myxoma virus, a double-stranded DNA virus of the pox family, harbors, antiapoptotic M11L, its virulence factor. Analysis of its, three-dimensional structure reveals that despite lacking any primary, sequence similarity to Bcl-2, it adopts a virtually identical protein, fold. This allows it to associate with BH3 domains, especially those of, Bax and Bak. We found that M11L acts primarily by sequestering Bax and, Bak, thereby blocking the killing action of these essential cell-death, mediators. These findings expand the family of protein sequences that act, like Bcl-2 to block apoptosis and support the conclusion that the, prosurvival action of these proteins critically depends on their ability, to bind and antagonize Bax and/or Bak. | ||
==About this Structure== | ==About this Structure== | ||
| - | 2JBY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 2JBY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Na Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JBY OCA]. |
| + | |||
| + | ==Reference== | ||
| + | A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak., Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM, Mol Cell. 2007 Mar 23;25(6):933-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17386268 17386268] | ||
[[Category: Myxoma virus]] | [[Category: Myxoma virus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: myxoma virus]] | [[Category: myxoma virus]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:59:26 2007'' |
Revision as of 17:49, 18 December 2007
|
A VIRAL PROTEIN UNEXPECTEDLY MIMICS THE STRUCTURE AND FUNCTION OF PRO-SURVIVAL BCL-2
Overview
Many viruses express antiapoptotic proteins to counter host defense, mechanisms that would otherwise trigger the rapid clearance of infected, cells. For example, adenoviruses and some gamma-herpesviruses express, homologs of prosurvival Bcl-2 to subvert the host's apoptotic machinery., Myxoma virus, a double-stranded DNA virus of the pox family, harbors, antiapoptotic M11L, its virulence factor. Analysis of its, three-dimensional structure reveals that despite lacking any primary, sequence similarity to Bcl-2, it adopts a virtually identical protein, fold. This allows it to associate with BH3 domains, especially those of, Bax and Bak. We found that M11L acts primarily by sequestering Bax and, Bak, thereby blocking the killing action of these essential cell-death, mediators. These findings expand the family of protein sequences that act, like Bcl-2 to block apoptosis and support the conclusion that the, prosurvival action of these proteins critically depends on their ability, to bind and antagonize Bax and/or Bak.
About this Structure
2JBY is a Protein complex structure of sequences from Myxoma virus with NA as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak., Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM, Mol Cell. 2007 Mar 23;25(6):933-42. PMID:17386268
Page seeded by OCA on Tue Dec 18 19:59:26 2007
