3ksw

From Proteopedia

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[[Category: Nadp]]
[[Category: Nadp]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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[[Category: Polymorphism]]
 
[[Category: Steroid biosynthesis]]
[[Category: Steroid biosynthesis]]
[[Category: Sterol 14-alpha demethylase]]
[[Category: Sterol 14-alpha demethylase]]
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[[Category: Transmembrane protein]]
[[Category: Transmembrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:35:02 2010''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:25:28 2010''

Revision as of 04:17, 25 August 2010

Template:STRUCTURE 3ksw

Crystal structure of sterol 14alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with an inhibitor VNF ((4-(4-chlorophenyl)-N-[2-(1H-imidazol-1-yl)-1-phenylethyl]benzamide)

Template:ABSTRACT PUBMED 20530488

About this Structure

3KSW is a 1 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

Reference

  • Lepesheva GI, Hargrove TY, Anderson S, Kleshchenko Y, Furtak V, Wawrzak Z, Villalta F, Waterman MR. Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi. J Biol Chem. 2010 Aug 13;285(33):25582-90. Epub 2010 Jun 8. PMID:20530488 doi:10.1074/jbc.M110.133215

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