2j6k
From Proteopedia
(New page: 200px<br /> <applet load="2j6k" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j6k, resolution 2.775Å" /> '''N-TERMINAL SH3 DOM...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2J6K is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J6K OCA]]. | + | 2J6K is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J6K OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: surface active protein]] | [[Category: surface active protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:54:35 2007'' |
Revision as of 08:49, 30 October 2007
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N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG)
Overview
The CIN85/CMS (human homologs of mouse SH3KBP1/CD2AP) family of endocytic, adaptor proteins has the ability to engage multiple effectors and couple, cargo trafficking with the cytoskeleton. CIN85 and CMS (Cas ligand with, multiple Src homology 3 (SH3) domains) facilitate the formation of large, multiprotein complexes required for an efficient internalization of cell, surface receptors. It has recently been shown that c-Cbl/Cbl-b could, mediate the formation of a ternary complex between one c-Cbl/Cbl-b, molecule and two SH3 domains of CIN85, important for the ability of Cbl to, promote epidermal growth factor receptor down-regulation. To further, investigate whether multimerization is conserved within the family of, adaptor proteins, we have solved the crystal structures of the CMS, ... [(full description)]
About this Structure
2J6K is a [Single protein] structure of sequence from [Homo sapiens] with NA as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain., Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J, J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:17020880
Page seeded by OCA on Tue Oct 30 10:54:35 2007
Categories: Homo sapiens | Single protein | Bravo, J. | Cardenes, N. | Deribe, Y.L. | Dikic, I. | Moncalian, G. | Spinola-Amilibia, M. | NA | Adaptor protein | Cd2 associated protein | Coiled coil | Cytoskeletal rearrangements | Egfr downregulation | Phosphorylation | Protein binding | Sh3 | Sh3 domain | Sh3-binding | Signaling protein | Surface active protein
