1gzu
From Proteopedia
(New page: 200px<br /> <applet load="1gzu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gzu, resolution 2.90Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GZU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NMN as [[http://en.wikipedia.org/wiki/ligand ligand]]. This structure superseeds the now removed PDB entry 1GRY. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.1 2.7.7.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZU OCA]]. | + | 1GZU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NMN as [[http://en.wikipedia.org/wiki/ligand ligand]]. This structure superseeds the now removed PDB entry 1GRY. Active as [[http://en.wikipedia.org/wiki/Nicotinamide-nucleotide_adenylyltransferase Nicotinamide-nucleotide adenylyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.1 2.7.7.1]]. Structure known Active Site: NMA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZU OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN., Werner E, Ziegler M, Lerner F, Schweiger M, Heinemann U, FEBS Lett. 2002 Apr 10;516(1-3):239-44. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11959140 11959140] | Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN., Werner E, Ziegler M, Lerner F, Schweiger M, Heinemann U, FEBS Lett. 2002 Apr 10;516(1-3):239-44. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11959140 11959140] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Nicotinamide-nucleotide adenylyltransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Heinemann, U.]] | [[Category: Heinemann, U.]] | ||
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[[Category: nad biosynthesis]] | [[Category: nad biosynthesis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:55:26 2007'' |
Revision as of 08:50, 30 October 2007
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CRYSTAL STRUCTURE OF HUMAN NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE IN COMPLEX WITH NMN
Overview
The final step in the biosynthesis of nicotinamide-adenine dinucleotide, a, major coenzyme in cellular redox reactions and involved in intracellular, signaling, is catalyzed by the enzyme nicotinamide mononucleotide, adenylyltransferase (NMNAT). The X-ray structure of human NMNAT in complex, with nicotinamide mononucleotide was solved by the single-wavelength, anomalous dispersion method at a resolution of 2.9 A. Human NMNAT is a, symmetric hexamer whose subunit is formed by a large six-stranded parallel, beta-sheet with helices on both sides. Human NMNAT displays a different, oligomerization compared to the archaeal enzyme. The protein-nicotinamide, mononucleotide interaction pattern provides insight into ligand binding in, the human enzyme.
About this Structure
1GZU is a [Single protein] structure of sequence from [Homo sapiens] with NMN as [ligand]. This structure superseeds the now removed PDB entry 1GRY. Active as [Nicotinamide-nucleotide adenylyltransferase], with EC number [2.7.7.1]. Structure known Active Site: NMA. Full crystallographic information is available from [OCA].
Reference
Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN., Werner E, Ziegler M, Lerner F, Schweiger M, Heinemann U, FEBS Lett. 2002 Apr 10;516(1-3):239-44. PMID:11959140
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