2ux8
From Proteopedia
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| - | [[Image:2ux8.gif|left|200px]]<br /> | + | [[Image:2ux8.gif|left|200px]]<br /><applet load="2ux8" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2ux8" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2ux8, resolution 2.65Å" /> | caption="2ux8, resolution 2.65Å" /> | ||
'''CRYSTAL STRUCTURE OF SPHINGOMONAS ELODEA ATCC 31461 GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE IN COMPLEX WITH GLUCOSE-1-PHOSPHATE.'''<br /> | '''CRYSTAL STRUCTURE OF SPHINGOMONAS ELODEA ATCC 31461 GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE IN COMPLEX WITH GLUCOSE-1-PHOSPHATE.'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2UX8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sphingomonas_elodea Sphingomonas elodea] with G1P as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/UTP--glucose-1-phosphate_uridylyltransferase UTP--glucose-1-phosphate uridylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.9 2.7.7.9] | + | 2UX8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sphingomonas_elodea Sphingomonas elodea] with G1P as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/UTP--glucose-1-phosphate_uridylyltransferase UTP--glucose-1-phosphate uridylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.9 2.7.7.9] Known structural/functional Site: <scene name='pdbsite=AC1:G1p Binding Site For Chain H'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UX8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: ugpg]] | [[Category: ugpg]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 20:20:35 2007'' |
Revision as of 18:10, 18 December 2007
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CRYSTAL STRUCTURE OF SPHINGOMONAS ELODEA ATCC 31461 GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE IN COMPLEX WITH GLUCOSE-1-PHOSPHATE.
Overview
Gellan gum is a widely used commercial material, available in many, different forms. Its economic importance has led to studies into the, biosynthesis of exopolysaccharide gellan gum, which is industrially, prepared in high yields using Sphingomonas elodea ATCC 31461., Glucose-1-phosphate uridylyltransferase mediates the reversible conversion, of glucose-1-phosphate and UTP into UDP-glucose and pyrophosphate, which, is a key step in the biosynthetic pathway of gellan gums. Here we present, the X-ray crystal structure of the glucose-1-phosphate uridylyltransferase, from S. elodea. The S. elodea enzyme shares strong monomeric similarity, with glucose-1-phosphate thymidylyltransferase, several structures of, which are known, although the quaternary structures of the active enzymes, are rather different. A detailed comparison between S. elodea, glucose-1-phosphate uridylyltransferase and available, thymidylyltransferases is described and shows remarkable structural, similarities, despite the low sequence identities between the two, divergent groups of proteins.
About this Structure
2UX8 is a Single protein structure of sequence from Sphingomonas elodea with G1P as ligand. Active as UTP--glucose-1-phosphate uridylyltransferase, with EC number 2.7.7.9 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The complex of Sphingomonas elodea ATCC 31461 glucose-1-phosphate uridylyltransferase with glucose-1-phosphate reveals a novel quaternary structure, unique among nucleoside diphosphate-sugar pyrophosphorylase members., Aragao D, Fialho AM, Marques AR, Mitchell EP, Sa-Correia I, Frazao C, J Bacteriol. 2007 Jun;189(12):4520-8. Epub 2007 Apr 13. PMID:17434970
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Categories: Single protein | Sphingomonas elodea | UTP--glucose-1-phosphate uridylyltransferase | Aragao, D. | Fialho, A.M. | Frazao, C. | Marques, A.R. | Mitchell, E.P. | Sa-Correia, I. | G1P | Galu pyrophosphorylase | Glucose-1-phosphate uridylyltransferase | Nucleotidyltransferase | Transferase | Ugpg
