2uym
From Proteopedia
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| - | [[Image:2uym.gif|left|200px]]<br /> | + | [[Image:2uym.gif|left|200px]]<br /><applet load="2uym" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2uym" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2uym, resolution 2.11Å" /> | caption="2uym, resolution 2.11Å" /> | ||
'''CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 37'''<br /> | '''CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 37'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2UYM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG, ADP and K03 as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 2UYM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG, ADP and K03 as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:K03 Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UYM OCA]. |
==Reference== | ==Reference== | ||
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[[Category: thiophene]] | [[Category: thiophene]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 20:22:13 2007'' |
Revision as of 18:12, 18 December 2007
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CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 37
Overview
We have identified and synthesized a series of thiophene containing, inhibitors of kinesin spindle protein. SAR studies led to the synthesis of, 33, which was co-crystallized with KSP and determined to bind to an, allosteric pocket previously described for other known KSP inhibitors.
About this Structure
2UYM is a Single protein structure of sequence from Homo sapiens with MG, ADP and K03 as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors., Pinkerton AB, Lee TT, Hoffman TZ, Wang Y, Kahraman M, Cook TG, Severance D, Gahman TC, Noble SA, Shiau AK, Davis RL, Bioorg Med Chem Lett. 2007 Apr 29;. PMID:17498954
Page seeded by OCA on Tue Dec 18 20:22:13 2007
Categories: Homo sapiens | Single protein | Lee, T.T. | ADP | K03 | MG | Atp-binding | Cell cycle | Cell division | Coiled coil | Complex | Eg5 | Inhibitor | Kinesin spindle protein | Ksp | Microtubule | Mitosis | Motor protein | Nucleotide-binding | Phosphorylation | Thiophene
