2v02
From Proteopedia
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| - | [[Image:2v02.gif|left|200px]]<br /> | + | [[Image:2v02.gif|left|200px]]<br /><applet load="2v02" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2v02" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2v02, resolution 2.20Å" /> | caption="2v02, resolution 2.20Å" /> | ||
'''RECOMBINANT VERTEBRATE CALMODULIN COMPLEXED WITH BA'''<br /> | '''RECOMBINANT VERTEBRATE CALMODULIN COMPLEXED WITH BA'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2V02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and BA as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 2V02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and BA as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Ba Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V02 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: ubl conjugation]] | [[Category: ubl conjugation]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 20:24:14 2007'' |
Revision as of 18:14, 18 December 2007
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RECOMBINANT VERTEBRATE CALMODULIN COMPLEXED WITH BA
Contents |
Overview
Calmodulin is a calcium sensor that is also capable of binding and being, activated by other metal ions. Of specific interest in this respect is, lead, which is known to be neurotoxic and to have a very high affinity, towards calmodulin. Crystal structures of human calmodulin complexed with, lead and barium ions have been solved. The results will help in, understanding the activation mechanisms of calmodulin by different heavy, metals and will provide a detailed view of a putative target for lead, neurotoxicity in humans.
Disease
Known diseases associated with this structure: Cavernous malformations of CNS and retina OMIM:[604214], Cerebral cavernous malformations-1 OMIM:[604214], Hyperkeratotic cutaneous capillary-venous malformations associated with cerebral capillary malformations OMIM:[604214], Leukemia, acute T-cell lymphoblastic OMIM:[603025], Leukemia, acute myeloid OMIM:[603025]
About this Structure
2V02 is a Single protein structure of sequence from Homo sapiens with CA and BA as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
A structural insight into lead neurotoxicity and calmodulin activation by heavy metals., Kursula P, Majava V, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt, 8):653-6. Epub 2007 Jul 28. PMID:17671360
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