1gzy
From Proteopedia
(New page: 200px<br /> <applet load="1gzy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gzy, resolution 2.54Å" /> '''HUMAN INSULIN-LIKE ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GZY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with C15 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZY OCA]]. | + | 1GZY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with C15 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: C15. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZY OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: plasma]] | [[Category: plasma]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:56:00 2007'' |
Revision as of 08:51, 30 October 2007
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HUMAN INSULIN-LIKE GROWTH FACTOR; IN-HOUSE DATA
Overview
Human insulin-like growth factors I and II (hIGF-I, hIGF-II) are potent, stimulators of cell and growth processes. They display high sequence, similarity to both the A and B chains of insulin but contain an additional, connecting C-domain, which reflects their secretion without specific, packaging or precursor conversion. IGFs also have an extension at the, C-terminus known as the D-domain. This paper describes four homologous, hIGF-1 structures, obtained from crystals grown in the presence of the, detergent SB12, which reveal additional detail in the C- and D-domains., Two different detergent binding modes observed in the crystals may reflect, different hIGF-I biological properties such as the interaction with IGF, binding proteins and self-aggregation. While the helical core of hIGF-I ... [(full description)]
About this Structure
1GZY is a [Single protein] structure of sequence from [Homo sapiens] with C15 as [ligand]. Structure known Active Site: C15. Full crystallographic information is available from [OCA].
Reference
Structural origins of the functional divergence of human insulin-like growth factor-I and insulin., Brzozowski AM, Dodson EJ, Dodson GG, Murshudov GN, Verma C, Turkenburg JP, de Bree FM, Dauter Z, Biochemistry. 2002 Jul 30;41(30):9389-97. PMID:12135360
Page seeded by OCA on Tue Oct 30 10:56:00 2007
