Calmodulin

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[[Image:1prw.png|left|200px|thumb|Crystal structure of bovine brain Ca++ calmodulin in a compact form, [[1prw]]]]
[[Image:1prw.png|left|200px|thumb|Crystal structure of bovine brain Ca++ calmodulin in a compact form, [[1prw]]]]
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{{STRUCTURE_1prw| PDB=1prw | SIZE=300| SCENE= |right|CAPTION=Calmodulin, [[1prw]] }}
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{{STRUCTURE_1prw| PDB=1prw | SIZE=300| SCENE=Calmodulin/Cv/1 |right|CAPTION=Calmodulin, [[1prw]] }}
Under contstruction...
Under contstruction...
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{{Clear}}
<applet load='1cll' size='350' color='white' frame='true' align='right' caption='Calmodulin' scene='Calmodulin/Inicio/1' />
<applet load='1cll' size='350' color='white' frame='true' align='right' caption='Calmodulin' scene='Calmodulin/Inicio/1' />
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<scene name='Calmodulin/Bound/3'>Bound</scene>
<scene name='Calmodulin/Bound/3'>Bound</scene>
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== 3D Structures of Calmodulin ==
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=== Native CaM ===
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[[1prw]], [[1deg]] – bCaM - bovine<br />
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[[1up5]] – cCaM – chicken<br />
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[[1clm]], [[1osa]], [[1exr]] – PtCaM - ''Paramecium tetraurelia''<br />
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[[3cln]] – rCaM - rat<br />
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[[1x02]], [[1dmo]] – XlCaM – NMR - ''Xenopus laevis''<br />
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[[2k61]], [[2k0e]] – hCaM – NMR - human<br />
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[[1y6w]], [[1cll]] - hCaM<br />
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[[4cln]] – DmCaM - ''Drosophila melanogaster''<br />
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[[1rfj]] – CaM – potato<br />
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[[1ooj]] – CaM – ''Caenorhabditis elegans''<br />
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=== Mutant CaM ===
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[[1ahr]] – cCaM (mutant)<br />
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[[2k0j]], [[1sw8]] – hCaM (mutant) – NMR<br />
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=== apo CaM ===
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[[1lkj]] – yapoCaM – NMR -yeast<br />
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[[1cfc]], [[1cfd]] - XlapoCaM – NMR<br />
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[[1qx5]] – rapoCaM – rat<br />
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=== CaM N-terminal ===
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[[2i08]] - hCaM N-terminal (mutant)<br />
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[[1j7o]] - hCaM N-terminal – NMR<br />
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[[1f70]] - XlCaM N-terminal – NMR <br />
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[[2ro8]], [[2roa]] - sCaM N-terminal+Ca – NMR - soybean<br />
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[[2ro9]], [[2rob]] - sCaM C-terminal+Ca – NMR<br />
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[[1j7o]], [[1j7p]] - hCaM N-terminal – NMR<br />
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[[3ifk]], [[3b32]] – rCaM N-terminal <br />
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[[1f54]], [[1f55]] – yapoCaM N-terminal – NMR<br />
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=== CaM C-terminal ===
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[[1f71]] - XlCaM C-terminal – NMR<br />
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[[1cmg]] – bCaM C-terminal – NMR<br />
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[[1fw4]] - bCaM C-terminal<br />
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[[1cmf]] – bapoCaM C-terminal – NMR<br />
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[[2hf5]] - hCaM EF2 EF3 – NMR<br />
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=== CaM+ cations (not calcium) ===
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[[2ksz]] – sCaM N-terminal+Mg – NMR <br />
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[[1ak8]] - bCaM N-terminal+Ce – NMR<br />
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[[2eqc]] – XlCaM C-terminal+Mg– NMR<br />
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[[2pq3]] – rCaM+Zn<br />
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[[2v01]] – hCaM+Pb<br />
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[[2v02]] – hCaM+Ba<br />
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[[1n0y]] – PtCaM+Pb <br />
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=== CaM small molecule complexes ===
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[[3if7]] – bCaM+sphingosylphosphorylcholine<br />
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[[1qiv]], [[1qiw]] – bCaM+DPDv
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[[1a29]], [[1lin]] – bCaM+trifluoperazine<br />
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[[1ctr]] - hCaM+trifluoperazine <br />
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[[2kug]], [[2kuh]] - hCaM N-terminal EF1 EF2+halothane – NMR<br />
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[[2kdu]] – XlCaM+MUNC13-1 – NMR<br />
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[[1mux]] – XlCaM+W-7 – NMR<br />
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=== CaM complexed with protein CBD domains ===
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[[3gp2]] – cCaM+CaM kinase II δ chain<br />
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[[3gof]], [[2o60]] – cCaM+nitric oxide synthase CBD<br />
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[[1niw]] - rCaM+nitric oxide synthase CBD <br />
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[[3hr4]] - hCaM+nitric oxide synthase CBD <br />
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[[2x0g]], [[1yr5]], [[1wrz]] – hCaM+death-associated protein kinase 1 (DAP)<br />
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[[2kne]] – hCaM+PMCA C-terminal CBD<br />
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[[3ewt]], [[3ewv]] – hCaM+TNFR fragment<br />
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[[2kn2]] – sCaM C-terminal+NtMKP1 CBD – NMR<br />
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[[2w73]], [[2jzi]], [[2r28]] – hCaM+Ser/Thr phosphatase CBD<br />
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[[3bya]] – hCaM+glutamate receptor peptide<br />
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[[2hqw]] - rCaM+glutamate receptor peptide<br />
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[[2k3s]] – CaM+smoothelin-like protein 1 – NMR<br />
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[[3g43]], [[2vay]], [[2f3y]], [[2f3z]], [[2be6]] – hCaM+calcium channel CAV1.2<br />
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[[3bxk]], [[3bxl]] – rCaM+ calcium channel peptide<br />
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[[1cff]] - XlCaM+ calcium channel CBD - NMR<br />
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[[1g4y]] - rCaM+ potassium channel CBD<br />
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[[1qx7]] – rapoCaM+potassium channel peptide<br />
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[[2o5g]] – cCaM+ myosin light chain kinase peptide<br />
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[[2ix7]] – apoCaM+myosin-5A<br />
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[[2k0f]] – hCaM+myosin light chain kinase peptide – NMR<br />
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[[2bbm]], [[2bbn]] - DmCaM+myosin light chain kinase <br />
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[[2bki]], [[2bkh]] – CaM+myosin VI – pig<br />
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[[1zuz]] – hCaM+DRP kinase peptide<br />
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[[2bcx]] – cCaM+ryanodine receptor 1 peptide<br />
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[[2fot]] - bCaM+α-II spectrin CBD<br />
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[[2f2o]], [[2f2p]] – bCaM+calcineurin CBD<br />
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[[2col]], [[2yrt]], [[2yru]] – BpCaM+adenyl cyclase – ''Bordetella pertussis''<br />
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[[1zot]] – BpCaM C-terminal+adenyl cyclase<br />
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[[1xfu]], [[1xfv]], [[1xfw]], [[1xfx]], [[1xfy]], [[1xfz]], [[1y0v]], [[1sk6]], [[1pk0]], [[1lvc]], [[1k90]], [[1k93]] - CaM+adenyl cyclase – ''Bacillus anthracis''<br />
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[[1sy9]] – XlCaM+olfactory channel peptide<br />
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[[1xa5]] – bCaM+KAR-2<br />
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[[1l7z]] – hCaM+CAP-23/NAP-22 CBD<br />
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[[1qs7]], [[1qtx]] – CaM+RS20 – ''Escherichia coli''<br />
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[[1vrk]] – CaM (mutant)+RS20<br />
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[[1nwd]] – XlCaM+glutamate decarboxylase CBD<br />
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[[1mxe]] – DmCaM+rCaMKI CBD <br />
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[[1iq5]] – XlCaM+CaM dependent kinase CBD<br />
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[[1cm1]], [[1cm4]], [[1cdm]] - bCaM+CaM dependent kinase CBD<br />
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[[1cdl]] - hCaM+CaM dependent kinase CBD<br />
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[[1ckk]] - XlCaM+CaM dependent kinase CBD - NMR<br />
==See Also==
==See Also==

Revision as of 08:28, 2 September 2010

Image:1prw.png
Crystal structure of bovine brain Ca++ calmodulin in a compact form, 1prw

Template:STRUCTURE 1prw

Under contstruction... Calmodulin (CaM) – calcium modulated protein – regulates various protein targets. It is used by various proteins as calcium sensor and signal transducer by binding to their calcium binding domain (CBD). It undergoes conformational change upon binding Ca++ via its 4 EF hand motives and can undergo post-translational modification. The images at the left and at the right correspond to one representative calmodulin, i.e. crystal structure of bovine brain Ca++ calmodulin in a compact form (1prw).

Contents

Calmodulin

Drag the structure with the mouse to rotate


Conformational change of Calmodulin

Calmodulin in Motion


,

3D Structures of Calmodulin

Native CaM

1prw, 1deg – bCaM - bovine
1up5 – cCaM – chicken
1clm, 1osa, 1exr – PtCaM - Paramecium tetraurelia
3cln – rCaM - rat
1x02, 1dmo – XlCaM – NMR - Xenopus laevis
2k61, 2k0e – hCaM – NMR - human
1y6w, 1cll - hCaM
4cln – DmCaM - Drosophila melanogaster
1rfj – CaM – potato
1ooj – CaM – Caenorhabditis elegans

Mutant CaM

1ahr – cCaM (mutant)
2k0j, 1sw8 – hCaM (mutant) – NMR


apo CaM

1lkj – yapoCaM – NMR -yeast
1cfc, 1cfd - XlapoCaM – NMR
1qx5 – rapoCaM – rat


CaM N-terminal

2i08 - hCaM N-terminal (mutant)
1j7o - hCaM N-terminal – NMR
1f70 - XlCaM N-terminal – NMR
2ro8, 2roa - sCaM N-terminal+Ca – NMR - soybean
2ro9, 2rob - sCaM C-terminal+Ca – NMR
1j7o, 1j7p - hCaM N-terminal – NMR
3ifk, 3b32 – rCaM N-terminal
1f54, 1f55 – yapoCaM N-terminal – NMR


CaM C-terminal

1f71 - XlCaM C-terminal – NMR
1cmg – bCaM C-terminal – NMR
1fw4 - bCaM C-terminal
1cmf – bapoCaM C-terminal – NMR
2hf5 - hCaM EF2 EF3 – NMR


CaM+ cations (not calcium)

2ksz – sCaM N-terminal+Mg – NMR
1ak8 - bCaM N-terminal+Ce – NMR
2eqc – XlCaM C-terminal+Mg– NMR
2pq3 – rCaM+Zn
2v01 – hCaM+Pb
2v02 – hCaM+Ba
1n0y – PtCaM+Pb


CaM small molecule complexes

3if7 – bCaM+sphingosylphosphorylcholine
1qiv, 1qiw – bCaM+DPDv 1a29, 1lin – bCaM+trifluoperazine
1ctr - hCaM+trifluoperazine
2kug, 2kuh - hCaM N-terminal EF1 EF2+halothane – NMR
2kdu – XlCaM+MUNC13-1 – NMR
1mux – XlCaM+W-7 – NMR


CaM complexed with protein CBD domains

3gp2 – cCaM+CaM kinase II δ chain
3gof, 2o60 – cCaM+nitric oxide synthase CBD
1niw - rCaM+nitric oxide synthase CBD
3hr4 - hCaM+nitric oxide synthase CBD
2x0g, 1yr5, 1wrz – hCaM+death-associated protein kinase 1 (DAP)
2kne – hCaM+PMCA C-terminal CBD
3ewt, 3ewv – hCaM+TNFR fragment
2kn2 – sCaM C-terminal+NtMKP1 CBD – NMR
2w73, 2jzi, 2r28 – hCaM+Ser/Thr phosphatase CBD
3bya – hCaM+glutamate receptor peptide
2hqw - rCaM+glutamate receptor peptide
2k3s – CaM+smoothelin-like protein 1 – NMR
3g43, 2vay, 2f3y, 2f3z, 2be6 – hCaM+calcium channel CAV1.2
3bxk, 3bxl – rCaM+ calcium channel peptide
1cff - XlCaM+ calcium channel CBD - NMR
1g4y - rCaM+ potassium channel CBD
1qx7 – rapoCaM+potassium channel peptide
2o5g – cCaM+ myosin light chain kinase peptide
2ix7 – apoCaM+myosin-5A
2k0f – hCaM+myosin light chain kinase peptide – NMR
2bbm, 2bbn - DmCaM+myosin light chain kinase
2bki, 2bkh – CaM+myosin VI – pig
1zuz – hCaM+DRP kinase peptide
2bcx – cCaM+ryanodine receptor 1 peptide
2fot - bCaM+α-II spectrin CBD
2f2o, 2f2p – bCaM+calcineurin CBD
2col, 2yrt, 2yru – BpCaM+adenyl cyclase – Bordetella pertussis
1zot – BpCaM C-terminal+adenyl cyclase
1xfu, 1xfv, 1xfw, 1xfx, 1xfy, 1xfz, 1y0v, 1sk6, 1pk0, 1lvc, 1k90, 1k93 - CaM+adenyl cyclase – Bacillus anthracis
1sy9 – XlCaM+olfactory channel peptide
1xa5 – bCaM+KAR-2
1l7z – hCaM+CAP-23/NAP-22 CBD
1qs7, 1qtx – CaM+RS20 – Escherichia coli
1vrk – CaM (mutant)+RS20
1nwd – XlCaM+glutamate decarboxylase CBD
1mxe – DmCaM+rCaMKI CBD
1iq5 – XlCaM+CaM dependent kinase CBD
1cm1, 1cm4, 1cdm - bCaM+CaM dependent kinase CBD
1cdl - hCaM+CaM dependent kinase CBD
1ckk - XlCaM+CaM dependent kinase CBD - NMR

See Also

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