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Cyclophilin
From Proteopedia
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Alexander Berchansky (Talk | contribs)
(New page: Crystal Structure of human Cyclophilin-A, 2x25 {{STRUCTURE_2x25| PDB=2x25 | SIZE=300| SCENE= |right|CAPTION=human Cyclophilin-A, 2x25 }} Cycl...)
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Revision as of 09:36, 2 September 2010
Image:2x25.png
Crystal Structure of human Cyclophilin-A, 2x25
Cyclophilin (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The Cyp-A/cyclosporin A complex inhibits organ rejection. Cyp-D is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug.
