1gz6
From Proteopedia
(New page: 200px<br /> <applet load="1gz6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gz6, resolution 2.38Å" /> '''(3R)-HYDROXYACYL-CO...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GZ6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with SO4 and NAI as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZ6 OCA]]. | + | 1GZ6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with SO4 and NAI as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Estradiol_17-beta-dehydrogenase Estradiol 17-beta-dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZ6 OCA]]. |
==Reference== | ==Reference== | ||
Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution., Haapalainen AM, Koski MK, Qin YM, Hiltunen JK, Glumoff T, Structure. 2003 Jan;11(1):87-97. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12517343 12517343] | Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution., Haapalainen AM, Koski MK, Qin YM, Hiltunen JK, Glumoff T, Structure. 2003 Jan;11(1):87-97. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12517343 12517343] | ||
| + | [[Category: Estradiol 17-beta-dehydrogenase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 29: | Line 30: | ||
[[Category: steroid biosynthesis]] | [[Category: steroid biosynthesis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:56:17 2007'' |
Revision as of 08:51, 30 October 2007
|
(3R)-HYDROXYACYL-COA DEHYDROGENASE FRAGMENT OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2
Overview
The crystal structure of (3R)-hydroxyacyl-CoA dehydrogenase of rat, peroxisomal multifunctional enzyme type 2 (MFE-2) was solved at 2.38 A, resolution. The catalytic entity reveals an alpha/beta short chain alcohol, dehydrogenase/reductase (SDR) fold and the conformation of the bound, nicotinamide adenine dinucleotide (NAD(+)) found in other SDR enzymes. Of, great interest is the separate COOH-terminal domain, which is not seen in, other SDR structures. This domain completes the active site cavity of the, neighboring monomer and extends dimeric interactions. Peroxisomal diseases, that arise because of point mutations in the dehydrogenase-coding region, of the MFE-2 gene can be mapped to changes in amino acids involved in, NAD(+) binding and protein dimerization.
About this Structure
1GZ6 is a [Single protein] structure of sequence from [Rattus norvegicus] with SO4 and NAI as [ligands]. Active as [Estradiol 17-beta-dehydrogenase], with EC number [1.1.1.62]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution., Haapalainen AM, Koski MK, Qin YM, Hiltunen JK, Glumoff T, Structure. 2003 Jan;11(1):87-97. PMID:12517343
Page seeded by OCA on Tue Oct 30 10:56:17 2007
