2v42
From Proteopedia
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| - | [[Image:2v42. | + | [[Image:2v42.jpg|left|200px]]<br /><applet load="2v42" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2v42" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2v42, resolution 2.75Å" /> | caption="2v42, resolution 2.75Å" /> | ||
'''CRYSTAL STRUCTURE OF RSEB: A SENSOR FOR PERIPLASMIC STRESS RESPONSE IN E. COLI'''<br /> | '''CRYSTAL STRUCTURE OF RSEB: A SENSOR FOR PERIPLASMIC STRESS RESPONSE IN E. COLI'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2V42 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with NDS as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 2V42 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with NDS as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Nds Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V42 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: sensor for periplasmic stress]] | [[Category: sensor for periplasmic stress]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 20:28:08 2007'' |
Revision as of 18:18, 18 December 2007
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CRYSTAL STRUCTURE OF RSEB: A SENSOR FOR PERIPLASMIC STRESS RESPONSE IN E. COLI
Overview
An elegant network of signal transduction has evolved in the bacterial, cell envelope to respond to environmental stress. It is initiated by, sensing unfavourable and harmful changes in the periplasm. The stress, signal is then transmitted by a controlled degradation of the, transmembrane anti-sigma-factor RseA that leads to the activation of the, alternative sigma factor sigma(E). The periplasmic protein RseB exerts a, crucial role in modulating the stability of RseA. RseB from Escherichia, coli has been crystallized and crystal structures were determined at 2.4 A, and at 2.8 A resolution. The protein forms a homodimer, with the monomer, composed of two domains. The large domain resembles an unclosed, beta-barrel that is structurally remarkably similar to a protein family, capable of binding the lipid anchor of lipoproteins. The small C-terminal, domain, connected to the large domain by a partially unstructured loop, is, responsible for interaction with RseA. On the basis of the structure of, RseB, we suggest that it acts as a sensor of periplasmic stress with a, dual functionality: it detects mislocalized lipoproteins and propagates, the signal to induce the sigma(E)-response.
About this Structure
2V42 is a Single protein structure of sequence from Escherichia coli with NDS as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The Structure of RseB: A Sensor in Periplasmic Stress Response of E. coli., Wollmann P, Zeth K, J Mol Biol. 2007 Jun 19;. PMID:17692869
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