3omv

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Revision as of 07:34, 15 September 2010

Image:3omv.jpg

Template:STRUCTURE 3omv

Crystal structure of c-raf (raf-1)

Template:ABSTRACT PUBMED 20130576

About this Structure

3OMV is a 2 chains structure with sequences from Homo sapiens. This structure supersedes the now removed PDB entry 3lb7. Full crystallographic information is available from OCA.

Reference

  • Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature. 2010 Mar 18;464(7287):431-5. Epub 2010 Feb 3. PMID:20130576 doi:10.1038/nature08833

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