3me6

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'''Unreleased structure'''
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[[Image:3me6.jpg|left|200px]]
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The entry 3me6 is ON HOLD until Paper Publication
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{{STRUCTURE_3me6| PDB=3me6 | SCENE= }}
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Authors: Gay, S.C., Roberts, A.G., Maekawa, K., Talakad, J.C., Hong, W.X., Zhang, Q., Stout, C.D., Halpert, J.R.
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===Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel===
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Description: Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 09:22:39 2010''
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==About this Structure==
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3ME6 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ME6 OCA].
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==Reference==
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<ref group="xtra">PMID:16373351</ref><ref group="xtra">PMID:15100217</ref><ref group="xtra">PMID:14563924</ref><ref group="xtra">PMID:17887776</ref><ref group="xtra">PMID:19397311</ref><references group="xtra"/>
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[[Category: Oryctolagus cuniculus]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Gay, S C.]]
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[[Category: Halpert, J R.]]
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[[Category: Hong, W X.]]
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[[Category: Maekawa, K.]]
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[[Category: Roberts, A G.]]
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[[Category: Stout, C D.]]
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[[Category: Talakad, J C.]]
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[[Category: Zhang, Q.]]
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[[Category: Cyp 2b4]]
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[[Category: Cyp lm2]]
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[[Category: Cytochrome p450 2b4]]
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[[Category: Membrane protein]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: P450]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:50:03 2010''

Revision as of 07:41, 15 September 2010

Image:3me6.jpg

Template:STRUCTURE 3me6

Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel

About this Structure

3ME6 is a 4 chains structure with sequences from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

  • Zhao Y, White MA, Muralidhara BK, Sun L, Halpert JR, Stout CD. Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction. J Biol Chem. 2006 Mar 3;281(9):5973-81. Epub 2005 Dec 21. PMID:16373351 doi:10.1074/jbc.M511464200
  • Scott EE, White MA, He YA, Johnson EF, Stout CD, Halpert JR. Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding. J Biol Chem. 2004 Jun 25;279(26):27294-301. Epub 2004 Apr 20. PMID:15100217 doi:10.1074/jbc.M403349200
  • Scott EE, He YA, Wester MR, White MA, Chin CC, Halpert JR, Johnson EF, Stout CD. An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13196-201. Epub 2003 Oct 16. PMID:14563924 doi:http://dx.doi.org/10.1073/pnas.2133986100
  • Zhao Y, Sun L, Muralidhara BK, Kumar S, White MA, Stout CD, Halpert JR. Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4. Biochemistry. 2007 Oct 16;46(41):11559-67. Epub 2007 Sep 22. PMID:17887776 doi:http://dx.doi.org/10.1021/bi7011614
  • Gay SC, Sun L, Maekawa K, Halpert JR, Stout CD. Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1Himidazole: ligand induced structural response through -helical repositioning. Biochemistry. 2009 Apr 27. PMID:19397311 doi:10.1021/bi9003765

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